EVALUATION OF SUBCHRONIC TOXICITY OF TRI THIEN DUOC HARD CAPSULE IN EXPERIMENTAL ANIMALS

Nguyen Thi Thanh Loan, Pham Thi Van Anh, Vu Thi Ngoc Thanh, Nguyen Thi Ngoc Tram

Tóm tắt


Tri Thien Duoc, a formulation of Portulaca oleracea L. and Amaranthus spinosus L., is aimed to treat hemorrhoids and other related conditions; however, the safety of this product’s long-term consumption has never been reported. The present study evaluated the subchronic toxicity of Tri Thien Duoc hard capsule  in experimental animals. Subchronic toxicity was studied in Wistar rats based on the  guidance of World Health Organization and Organisation for Economic Co-operation and Development. The rats were treated with the doses of 0.566 g extract/kg per day and 1.698 g extract/kg per day for a period of 90 consecutive days. Tri Thien Duoc hard capsule caused no significant dose-related changes in general status, hematological parameters, renal and hepatic function tests; in addition, it did not cause any change in histology of the liver and kidney of the rats. Our finding obtained that the Tri Thien Duoc hard capsule did not cause subchronic toxicity in experimental animals.

 


Từ khóa


Tri Thien Duoc, subchronic toxicity, experimental ani

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Tài liệu tham khảo


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