IDENTIFICATION OF THE POLYMORPHISM RS4072037 OF MUC1 GENE IN PATIENTS WITH GASTRIC CANCER

Nguyen Thi Ngoc Lan, Nguyen Van Tan, Dang Thi Ngoc Dung

Tóm tắt


Gastric cancer, a malignant disease, is the fourth most common cancer and second most common cause of cancer death. The pathogenesis of gastric cancer is a complex process, including Helicobacter pylori infection, genetic factors as well as many other factors. Among them, Single Nucleotide Polymorphism (SNP) is one of the most interesting topics nowadays. Few studies on rs4072037 polymorphisms of the MUC1 gene have been done  in different populations, particularly in Asian populations, which have indicated its role and significance as a susceptibility factor to gastric cancerL. Our objective was to see if this varitation can be detected in Vietname patients with gastric cancer. Methods: 130 patients diagnosed of gastric cancer and 130 healthy controls were recruited from the 4 largest hospitals in the North Vietnam. Genetic polymorphism at rs4072037 was determined by PCR-RFLP. Results: Three types of SNPs were found as the allele type (G vs A: OR = 0.42, 95% CI: 0.25-0.72), the heterologeneous gene type (AG vs. AA, OR = 0.47, 95% CI: 0.28-0.77) and dominant gene type (AG + AA vs. GG: OR = 0.67, 95% CI: 0.47-0.97). Conclusions: Allele G of rs4072037 associated with the reduction of gastric cancer risk.


Từ khóa


gastric cancer, polymorphism, rs4072037, MUC1 gene

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