Nguyen Hoai Bac, Nguyen Cao Thang, Hoang Long

Tóm tắt

The objective was to evaluate the relation between varicocele and sperm DNA fragmentation index (DFI) in infertile men. Materials and methods:  A controlled observational study recruited 205 patients who sought medical consultation at Hanoi Medical University Hospital. One-hundred and forty-two men were diagnosed with male infertility who had unilateral varicocele belonged to the varicocele group and 63 men with normal reproductive health belonged to the control group. Results: The mean DFI was significantly higher in the varicocele group compared with the control group (31.8 ± 18.8% compared with 22.6 ± 10.6%,with p < 0.01). The statistical difference in the percentage of severe DFI (  30%) between the two groups was recognized in this study (45.8% in the varicocele group compared with 20.6% in the control group, with p < 0.03). Some factors which were found to increase the level of DFI were age and infertility duration in patients with varicocele. However, there was no difference in the level of DFI among the three groups of varicocele grade. Conclusion: Varicocele has negative effects on sperm DFI. Therefore, varicocele should be treated early in infertile men, disregarding the grade of varicocele.

Từ khóa

Varicocele, semen analysis, sperm DNA fragmentation, DFI

Toàn văn:


Tài liệu tham khảo

Mohammed, A. and F. Chinegwundoh (2009), Testicular varicocele: an overview. Urol Int, . 82(4), 373 - 379.

Ficarra, V., et al. (2012), Varicocele repair for infertility: what is the evidence? Curr Opin Urol, 22(6), 489 - 494.

Agarwal, A., et al. (2007), Efficacy of Varicocelectomy in Improving Semen Parameters: New Meta-analytical Approach. Urology, 70(3), 532 - 538.

Zini, A., et al. (2011), Effect of microsurgical varicocelectomy on human sperm chromatin and DNA integrity: a prospective trial. Int J Androl, 34(1), 14 - 19.

Saleh, R.A., et al. (2003), Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertil Steril, 80(6), 1431 - 1436.

Abdel-Meguid, T.A., et al (2011), Does varicocele repair improve male infertility? An evidence-based perspective from a randomized, controlled trial. Eur Urol, 59(3), 455 - 461.

Ghazi, S. and H. Abdelfattah (2011), Effect of microsurgical varicocelectomy on sperm DNA fragmentation in infertile men. Middle East Fertility Society Journal, 16(2), 149 -153.

Mohamed, E.E., M. Gawish, and A. Mohamed (2017), Semen parameters and pregnancy rates after microsurgical varicocelectomy in primary versus secondary infertile men. Hum Fertil (Camb), 20(4), 293 - 296.

Practice Committee of the American Society for Reproductive, M., R (2014), Society for Male, and Urology, Report on varicocele and infertility: a committee opinion. Fertil Steril, 102(6), 1556 - 1560.

Simon, L., et al (2010), Clinical significance of sperm DNA damage in assisted reproduction outcome. Hum Reprod, 25(7), 1594 - 1608.

Wang, Y.J., et al (2012), Relationship between varicocele and sperm DNA damage and the effect of varicocele repair: a meta-analysis. Reprod Biomed Online, 25(3), 307 - 314.

Al Omrani, B., et al (2018), Associations of sperm DNA fragmentation with lifestyle factors and semen parameters of Saudi men and its impact on ICSI outcome. Reprod Biol Endocrinol, 16(1), 49.