IMMUNOSTIMULATORY EFFECT OF MORINGA OLEIFERA LEAVES EXTRACT ON CYCLOPHOSPHAMIDE-INDUCED IMMUNOSUPPRESSION IN MICE

Luong Minh Hien, Huynh Thanh Trang, Đinh Thi Thu Hang, Mai Phuong Thanh, Pham Thi Van Anh

Tóm tắt


The objective of this study was to evaluate the immunostimulatory activity of Moringa Oleifera extract. We induced the immunosuppression in Swiss mice by cyclophosphamide (CP). Moringa Oleifera leaves extract 0.74 g/kg body weight was administered orally 7 consecutive days to animals and CP (200 mg/kg i.p.) was injected on 4th day. The result showed that Moringa Oleifera leaves extract 0.74 g/kg ameliorated the effects of CP on delayed type hypersensitivity (DTH) response, leukocyte quantity, relative organ weight, IgM concentration and micro-histological images. This suggested the potential of Moringa Oleifera leaves extract to treat immunosuppression diseases in clinical practice.

Từ khóa


Immunostimulatory activity, Immunosuppression, Swiss mice, Cyclophosphamide, Moringa Oleifera leaves.

Toàn văn:

PDF

Tài liệu tham khảo


Yuan Gong, Jin Wu and Shi-Tong Li (2015). Immuno-enhancement effects of Lycium ruthenicum Murr. polysaccharide on cyclophosphamide-induced immunosuppression in mice. Int J Clin Exp Med, 8(11), 20631 - 20637.

U.S. Patil, A.V.Jaydeokar and D.D.Bandawane (2012). Immunomodulators: a pharmacological review. Int J Pharm Pharm Sci, 4(1), 30 - 36.

Jantan I, Ahmad W and Bukhari SN (2015). Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci, 6 - 655.

Gopalakrishnan L, Kruthi D, Devarai Sku (2016). Moringa oleifera: A review on nutritive importance and its medicinal application. Food Science and Human Wellness, 5(2), 49 - 56.

Nfambi J, Bbosa GS, Sembajwe LF, et al (2015). Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in Wistar albino rats. J Basic Clin Physiol Pharmacol, 26(6), 603 - 611.

H P Rang, J M Ritter, R J Flower, et al (2015), Rang and Dale’s pharmacology, eighth edition, Elsiver, UK.

Delved TJ, Roitt IM (1998), Encyclopedia of immunology, 2nd edition, Academic Press, London, 198 - 231.

Katzung GB (2011), Basic and Clinical Pharmacology, twelth edition, McGraw-Hill Companies, Inc.

Sudha P, Asdaq SM, Dhamingi SS, et al (2010). Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in animals. Indian J Physiol Pharmacol, 54(2), 133 - 40.

Ojeka SO, Dapper DV and Okerengwo AA (2018). Reversibility capacity of aqueous extract of moringa oleifera leaf on cyclophosphamide induced immunotoxicity in male Wistar rats. Journal of Advances in Medical and Pharmaceutical Sciences, 16(1), 1 - 8.