TY - JOUR AU - Bac, Nguyen Hoai AU - Long, Hoang PY - 2021/09/30 Y2 - 2024/03/28 TI - Study on clinical and genetic characteristics of male patients with non-obstructive azoospermia JF - Tạp chí Nghiên cứu Y học JA - TCNCYH VL - 141 IS - 5 SE - DO - 10.52852/tcncyh.v141i5.211 UR - https://tapchinghiencuuyhoc.vn/index.php/tcncyh/article/view/211 SP - 39-45 AB - <p>`We examined 501 patients with non - obstructive azoospermia to evaluate clinical, subclinical, and genetic characteristics. The results show that the average age of patients in the study was 29.8 ± 5.5 years. Primary infertility accounts for the majority, with a rate of 90.3%. There was 38.6% of patients had a history of mumps orchitis. The average levels of FSH, LH, testosterone were 31.6 ± 16.5 mIU/mL, 15.5 ± 10 mIU/mL and 12.8 ± 7.13 nmol/L, respectively. The prevalence of chromosomal abnormalities was 30.7%. Of these, the sex chromosome aneuploidy with 47,XXY karyotype (Klinefelter syndrome) accounted for 27.3%. The incidence of AZF microdeletion was 13.8%. Of these, AZFc deletion was the most common at the rate of 42.1%, AZFa deletion, which accounted for 2.6%, were the least prevalent, and the frequency of AZFd deletion was 5.3%. However, there was no solitary AZFb deletion, which combined with other AZF deletions with 34.2%. Our research shows that mumps orchitis and chromosomal abnormalities are the leading causes of azoospermia. Screening for genetic abnormalities plays an important role in infertile patients with non - obstructive azoospermia. </p> ER -