TY - JOUR AU - Phuong, Pham Thuy AU - Binh, Pham Quoc AU - Minh, Dinh Thi Hong AU - Hien, Tran Thi Thu AU - Thong, Nguyen Trong AU - Anh, Pham Thi Van AU - Hien, Dang Thi Thu PY - 2021/09/30 Y2 - 2024/03/29 TI - Effects of Hamo NK hard capsule on serum lipid profiles in dyslipidemia experimental animals JF - Tạp chí Nghiên cứu Y học JA - TCNCYH VL - 141 IS - 5 SE - DO - 10.52852/tcncyh.v141i5.217 UR - https://tapchinghiencuuyhoc.vn/index.php/tcncyh/article/view/217 SP - 10-18 AB - <p>Dyslipidemia is a major risk factor for cardiovascular disease. Polyherbal formulation is a traditional therapeutic strategy used to treat dyslipidemia over many years of tradition. The aim of this study was designed to evaluate the effects of Hamo NK hard capsule on endogenous dyslipidemia and exogenous dyslipidemia experimental animal model. In endogenous hyperlipidemia model, mice were previously treated by Hamo NK hard capsule, and intraperitoneally injected by poloxamer - 407 to induce hyperlipidemia. Rats were oral administration of oil - cholesterol mixture and Hamo NK for 4 consecutive weeks (exogenous dyslipidemia). Parameters of serum lipid were determined. Hamo NK ameliorated the elevation of serum total cholesterol, Non - HDL - cholesterol at the daily dose of 1.5g/kg b.w (p &lt; 0.05). Also, there was no signicant difference in increase on high - density lipoprotein cholesterol levels and decrease triglyceride levels between the groups. Hamo NK at two doses of 0.25g/kg b.w and 0.75g/kg b.w significantly reduced serum LDL - C levels compared to the cholesterol control group. Hamo NK hard capsule affected on serum lipid modulations in dyslipidemia models.</p> ER -