5. Evaluate the Sars- Cov-2 diagnostic value of quantitative antigen test

Dinh Thi Ngoc Quynh, Nguyen Duc Tuan, Nguyen Thi Ngoc Lan

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Tóm tắt

One of the most successful strategies to halt the spread of the COVID-19 pandemic is to quickly screen by testing to identify infected individuals, leading to effectively isolating patients. However, in order to ensure the test's value, the diagnostic value must be thoroughly analyzed before using it. In this research, we used a cross-sectional descriptive study to evaluate the diagnostic efficacy of the Lumipulse G SARS-COV-2 Ag test on salivary and nasopharyngeal swab specimens. The results showed that at the manufacturer's recommended cut-off of 0.67 pg/mL, the sensitivity and specificity were 70.00% and 68.87% on saliva samples, respectively. The test's sensitivity and specificity for nasopharyngeal swab samples were 100% and 95.9%, respectively, at the 1.34 pg/mL cut-off, and it could achieve high sensitivity of 99.4% and specificity of 99.3% at the cut-off value of 17.66 pg/mL. With nasopharyngeal swab samples, we found that the Lumipulse G SARS-COV-2 Ag test achieved the WHO testing standards for the diagnosis and screening of COVID-19. The sensitive diagnostic of this test in nasopharyngeal swab samples is high even the viral load is low and higher than in saliva swab samples.

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Tài liệu tham khảo

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