10. Subchronic toxicity assessments of silymax complex capsules in wistar rats

Pham Thi Van Anh, Vu Viet Hang, Nguyen Thi Minh Nguyet, Pham Thi Thu, Tran Thi Thuy, Tran Viet Dung, Dinh Thi Thu Hang

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Tóm tắt

It has recently become obvious that the prevalence of adults with diagnosed liver diseases has been rapidly increasing in Vietnam, as well as other countries, over the past two decades. There has been a current trend for researchers to discover new natural ingredients which were safe and still effective in the treatment of liver diseases. Silymax Complex was a herbal-derived product (Carduus marianus, Extractum Herba Phyllanthi urinariae, Extractum Fructus Schisandrae, Extractum Herba Adenosmatis caerulei and Curcuma longa L.) used as an oral medication. So far, the safety of this product has not been reported in Vietnam. Thus, this study was designed to assess the subchronic toxicity of Silymax Complex capsules in Wistar rats. The method used in this study followed the guidance of World Health Organization and Organization for Economic Co-operation and Development in rats with 2 oral doses of 316.8 mg/kg b.w/day and 950.4 mg/kg b.w/day for 12 consecutive weeks. As a result, Silymax Complex capsules caused no significant changes in general condition, hematological indexes, hepato-renal functions and microscopic images of livers and kidneys. In light of our findings, Silymax Complex capsules did not cause subchronic toxicity in experimental rats. Moreover, this also revealed partly the safety of Silymax Complex capsules in clinical practice.

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Tài liệu tham khảo

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