15. Studies on immunostimulatory effect of efcovida powder on Cyclophosphamide-induced immunosuppression in mice

Do Linh Quyen, Nguyen Ngoc Dieu Dieu, Tran Viet Dung, Trinh Dinh Nang , Nguyen Minh Hai , Tran Thi Thu Huong, Vo Quang Tuyen, Dinh Thi Thu Hang, Pham Thi Van Anh

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Tóm tắt

To evaluate the immunostimulatory activity of Efcovida powder, we induced immunosuppression in Swiss mice by cyclophosphamide (CP). Efcovida powder at two doses of 60 mg/kg b.w and 120 mg/kg b.w were administered orally for seven consecutive days to animals. CP (200 mg/kg i.p.) was injected on the 4th day. The result showed that Efcovida powder at the dose of 60 mg/kg b.w only posed an immunostimulating potency in the cyclophosphamide-induced immunosuppression model while Efcovida powder at the dose of 120 mg/kg b.w significantly ameliorated the effects of CP on delayed-type hypersensitivity (DTH) response, leukocyte quantity, relative thymus weight, serum IL-4, IL-6 concentration, and micro-histological images of spleen and thymus. This suggested the potential of Efcovida powder to treat immunosuppression diseases in clinical practice.

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Tài liệu tham khảo

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