15. Hyperuricemia and testosterone deficiency: An underestimated correlation

Nguyen Hoai Bac, Dinh Huu Viet, Tran Van Kien

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Tóm tắt

Hyperuricemia and testosterone deficiency (TD) are two relatively common conditions in clinical practice. We conducted the present study on 9573 men to evaluate the association between the two conditions and establish a hypothetic explanation. Compared with the normal group, the hyperuricemia group has lower testosterone level (14.79 ± 5.55 vs. 17.12 ± 6.24, p < 0.001) and lower LH level (5.57 ± 3.31 vs. 5.75 ± 3.21, p = 0.003). There is a weak negative correlation between testosterone and serum uric acid (SUA) after adjusting for confounding factors (Spearman's Rho = -0.2, p < 0.001). On linear regression, serum uric acid corresponds to testosterone with the formula: Testosterone = -0.015 x SUA + 22.37. We hypothesize that the mechanism underlying testosterone deficiency in hyperuricemia patients is due to an inhibition of LH release of the pituitary. Further studies are needed to examine this hypothesis.

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Tài liệu tham khảo

1. Rastrelli G, Corona G, Maggi M. Testosterone and sexual function in men. Maturitas. 2018; 112: 46-52. doi:10.1016/j.maturitas. 2018.04.004
2. Ramos GK, Goldfarb DS. Update on Uric Acid and the Kidney. Curr Rheumatol Rep. 2022; 24(5): 132-138. doi:10.1007/s11926-022-01069-3.
3. Ali N, Perveen R, Rahman S, et al. Prevalence of hyperuricemia and the relationship between serum uric acid and obesity: A study on Bangladeshi adults. PLoS One. 2018; 13(11) :e0206850. doi:10.1371/journal.pone.0206850.
4. Cao W, Zheng RD, Xu SH, Fan YF, Sun HP, Liu C. Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes. Int J Endocrinol. 2017; 2017: 4375253. doi:10.1155/2017/4375253.
5. Barbonetti A, D’Andrea S, Francavilla S. Testosterone replacement therapy. Andrology. 2020; 8(6): 1551-1566. doi:10.1111/andr.12774.
6. Gao F, Jiang B, Cang Z, et al. Serum Uric Acid Is Associated with Erectile Dysfunction: A Population-Based Cross-Sectional Study in Chinese Men. Sci Rep. 2017; 7(1): 2087. doi:10.1038/s41598-017-02392-x.
7. Tsai MK, Hung KC, Liao CC, Pan LF, Hung CL, Yang DH. The Association between Serum Testosterone and Hyperuricemia in Males. J Clin Med. 2022; 11(10): 2743. doi:10.3390/jcm11102743.
8. Kwong JCC, Krakowsky Y, Grober E. Testosterone Deficiency: A Review and Comparison of Current Guidelines. J Sex Med. 2019; 16(6): 812-820. doi:10.1016/j.jsxm.2019.03.262.
9. Thanh TN, Luu PD. Roles of Testosterone in Men with Type 2 Diabetes: A Review. In: Toi VV, Lien Phuong TH, eds. 5th International Conference on Biomedical Engineering in Vietnam. IFMBE Proceedings. Springer International Publishing; 2015: 281-284. doi:10.1007/978-3-319-11776-8_68.
10. Saito Y, Tanaka A, Node K, Kobayashi Y. Uric acid and cardiovascular disease: A clinical review. Journal of Cardiology. 2021; 78(1): 51-57. doi:10.1016/j.jjcc.2020.12.013.
11. Fukai S, Akishita M, Miyao M, Ishida K, Toba K, Ouchi Y. Age-related changes in plasma androgen levels and their association with cardiovascular risk factors in male Japanese office workers. Geriatr Gerontol Int. 2010; 10(1): 32-39. doi:10.1111/j.1447-0594.2009.00552.x.
12. Krysiak R, Gilowski W, Okopień B. The effect of testosterone on cardiovascular risk factors in men with type 2 diabetes and late-onset hypogonadism treated with metformin or glimepiride. Pharmacological Reports. 2016; 68(1): 75-79. doi:10.1016/j.pharep. 2015.06.003.
13. Cao W, Zheng RD, Xu SH, Fan YF, Sun HP, Liu C. Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes. Int J Endocrinol. 2017; 2017:4375253. doi:10.1155/2017/4375253.
14. Naamneh Elzenaty R, du Toit T, Flück CE. Basics of androgen synthesis and action. Best Practice & Research Clinical Endocrinology & Metabolism. 2022; 36(4): 101665. doi:10.1016/j.beem.2022.101665.
15. Muscelli E, Natali A, Bianchi S, et al. Effect of insulin on renal sodium and uric acid handling in essential hypertension. Am J Hypertens. 1996; 9(8): 746-752. doi:10.1016/0895-7061(96)00098-2.
16. Quiñones-Galvan A, Ferrannini E. Renal effects of insulin in man. J Nephrol. 1997; 10(4): 188-191.
17. Baldwin W, McRae S, Marek G, et al. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 2011; 60(4): 1258-1269. doi:10.2337/db10-0916.