25. Title of the article: Cigarette smoking and its association with hiv viral load among HIV-positive opioid users in Vietnam

Nguyen Truong Giang, Nguyen Van Huy, Nguyen Bich Diep, Nguyen Thu Trang, Le Minh Giang

Nội dung chính của bài viết

Tóm tắt

The study aimed to determine the smoking prevalence and explore the association between smoking and viral load among people living with HIV who are drug users (HIV+ PWID) in Vietnam. We used secondary data from a descriptive cross-sectional study of 280 HIV+ PWID in an open-label, non-inferiority trial from July 2015 to February 2018 at six HIV clinics in Northern Vietnam. The results showed that 82.1% of the participants reported daily smoking, and among them, 53.5% were classified as heavy smokers. After controlling for confounding factors, using non-smokers as the reference group, we found no association between cigarette smoking and HIV viral load. However, the study also revealed a large number of patients with co-infections such as HBV, HCV, TB, STIs (81.3%), and over half of the patients (51.4%) reported depression ranging from mild to severe. Considering the adverse health effects of smoking, it is crucial to integrate tobacco cessation programs and specialized treatments for other health issues in this key population. More longitudinal studies are needed to better understand this relationship.

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Tài liệu tham khảo

1. Bartal M. Heath effects of tobacco use and exposure. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo. 2002; 56: 545-554.
2. Das SK. Harmful health effects of cigarette smoking. Mol Cell Biochem. 2003; 253(1): 159-165. doi:10.1023/A:1026024829294.
3. Nguyen NPT, Tran BX, Hwang LY, et al. Prevalence of Cigarette Smoking and Associated Factors in a Large Sample of HIV-Positive Patients Receiving Antiretroviral Therapy in Vietnam. Ho W, ed. Plos one. 2015; 10(2): e0118185. doi:10.1371/journal.pone.0118185.
4. UNAIDS. (2022). Country factsheets Viet Nam.pdf.
5. Khajehkazemi R, Osooli M, Sajadi L, et al. HIV prevalence and risk behaviours among people who inject drugs in Iran: the 2010 National Surveillance Survey. Sex Transm Infect. 2013; 89(Suppl 3): iii29-iii32. doi:10.1136/sextrans-2013-051204.
6. Chockalingam L, Pence B, Frangakis CE, et al. The relationship between health-related variables and increases in smoking among recently diagnosed HIV+ people who inject drugs in Vietnam. Addictive Behaviors. 2019; 95: 118-124. doi:10.1016/j.addbeh.2019.03.008.
7. Brown JL, Winhusen T, DiClemente RJ, et al. The association between cigarette smoking, virologic suppression, and CD4+ lymphocyte count in HIV-Infected Russian women. AIDS Care. 2017; 29(9): 1102-1106. doi:10.1080/09540121.2017.1327645.
8. Ande A, McArthur C, Ayuk L, et al. Effect of Mild-to-Moderate Smoking on Viral Load, Cytokines, Oxidative Stress, and Cytochrome P450 Enzymes in HIV-Infected Individuals. Ho W, ed. PLoS ONE. 2015; 10(4): e0122402. doi:10.1371/journal.pone.0122402.
9. Feldman DN, Feldman JG, Greenblatt R, et al. CYP1A1 GENOTYPE MODIFIES THE IMPACT OF SMOKING ON EFFECTIVENESS OF HAART AMONG WOMEN. AIDS Educ Prev. 2009; 21(3 Suppl):81-93. doi:10.1521/aeap.2009.21.3_supp.81.
10. Impact of tobacco use on the development of opportunistic respiratory infections in HIV seropositive patients on antiretroviral therapy - MIGUEZ-BURBANO - 2003 - Addiction Biology - Wiley Online Library. https://onlinelibrary.wiley.com/doi/abs/10.1080/1355621031000069864. Accessed September 26, 2022.
11. Cropsey KL, Willig JH, Mugavero MJ, et al. Cigarette Smokers are Less Likely to have Undetectable Viral Loads: Results from Four HIV Clinics. J Addict Med. 2016; 10(1): 13-19. doi:10.1097/ADM.0000000000000172.
12. Kabali C, Cheng DM, Brooks DR, Bridden C, Horsburgh CR, Samet JH. Recent cigarette smoking and HIV disease progression: no evidence of an association. AIDS Care. 2011; 23(8): 947-956. doi:10.1080/09540121.2010.542128.
13. Webb MS, Vanable PA, Carey MP, Blair DC. Cigarette Smoking among HIV+ Men and Women: Examining Health, Substance Use, and Psychosocial Correlates across the Smoking Spectrum. J Behav Med. 2007; 30(5): 371-383. doi:10.1007/s10865-007-9112-9.
14. Korthuis PT, King C, Cook RR, et al. HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial. The Lancet HIV. 2021; 8(2): e67-e76. doi:10.1016/S2352-3018(20)30302-7.
15. Okuyemi, Kolawole S., et al. “Differences in smoking and quitting experiences by levels of smoking among African Americans.” Ethnicity & disease 14.1 (2004): 127-133.
16. Bradley KA, DeBenedetti AF, Volk RJ, Williams EC, Frank D, Kivlahan DR. AUDIT-C as a Brief Screen for Alcohol Misuse in Primary Care. Alcoholism: Clinical and Experimental Research. 2007; 31(7): 1208-1217. doi:10.1111/j.1530-0277.2007.00403.x.
17. Le MTH, Tran TD, Holton S, Nguyen HT, Wolfe R, Fisher J. Reliability, convergent validity and factor structure of the DASS-21 in a sample of Vietnamese adolescents. PLOS ONE. 2017; 12(7): e0180557. doi:10.1371/journal.pone.0180557.
18. Mohan C, Ha TV, Hoffman I, Eron J, Go V. Viral Hepatitis among HIV+ Patients in Northern Vietnam. Open Forum Infectious Diseases. 2017; 4(suppl_1): S661-S661. doi:10.1093/ofid/ofx163.1763.
19. Levintow SN, Pence BW, Ha TV, et al. Prevalence and predictors of depressive symptoms among HIV-positive men who inject drugs in Vietnam. Moitra E, ed. PLoS ONE. 2018; 13(1): e0191548. doi:10.1371/journal.pone.0191548.
20. Byrd KK, Hou JG, Hazen R, et al. Antiretroviral Adherence Level Necessary for HIV Viral Suppression Using Real-World Data. J Acquir Immune Defic Syndr. 2019; 82(3): 245-251. doi:10.1097/QAI.0000000000002142.