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Đã xuất bản: 2023-12-31
Số lượt xem tóm tắt: 102
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DOI: https://doi.org/10.52852/tcncyh.v173i12E13.2143
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Tập 173 Số 12E13 (2023)
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Cách trích dẫn
Anh, P. T. V., Mai, D. P., Binh, P. Q., Ngan, N. T. K., Dung, T. V., Thuy, N. T., Hang, V. V., & Hang, D. T. T. (2023). 11. Investigation of immunomodulatory activity of hericium erinaceus on cyclophosphamide-induced immunosuppression in mice. Tạp Chí Nghiên cứu Y học, 173(12E13), 87-93. https://doi.org/10.52852/tcncyh.v173i12E13.2143

11. Investigation of immunomodulatory activity of hericium erinaceus on cyclophosphamide-induced immunosuppression in mice

Pham Thi Van Anh, Dinh Phuong Mai, Pham Quoc Binh, Nguyen Thi Kim Ngan, Tran Viet Dung, Nguyen Thi Thuy, Vu Viet Hang, Dinh Thi Thu Hang

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Tóm tắt

The study  was conducted to assess the immunostimulatory effect of Hericium Erinaceus on cyclophosphamide-induced immunodeficient mice. Animals were  administered Hericium Erinaceus orally at 0.72 g/kg b.w and 1.44 g/kg b.w for seven consecutive days. On the 4th day, CP (200 mg/kg) was intraperitoneally injected into mice. The results illustrated that Hericium Erinaceus at 0.72 g/kg b.w only posed an immunostimulating potency in the cyclophosphamide-induced immunosuppression model. Besides, Hericium Erinaceus at 1.44 g/kg b.w ameliorated the effects of CP on delayed-type hypersensitivity (DTH) response, relative spleen weight, serum IL-2, TNF-α concentration, and micro-histological images of spleen and thymus substantially. This suggested the potential of Hericium Erinaceus to treat immunosuppression diseases in clinical practice.

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Từ khóa

Hericium Erinaceus, immunostimulatory effect, mice, cyclophosphamide.

Tài liệu tham khảo

1. Poon MML and Farber DL. The Whole Body as the System in Systems Immunology. iScience. 2020 Aug 28; 23(9): 101509.
2. Marshall JS, Warrington R, Watson W, et al. An introduction to immunology and immunopathology. Allergy Asthma Clin Immunol. 2018 Sep 12; 14(Suppl 2):49.
3. Jantan I, Ahmad W and Bukhari SN. Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci. 2015; 6 - 655.
4. Yang Y, Li J, Hong Q, et al. Polysaccharides from Hericium erinaceus Fruiting Bodies: Structural Characterization, Immunomodulatory Activity and Mechanism. Nutrients. 2022 Sep 9; 14(18):3721.
5. Yu R, Sun M, Meng Z, et al. Immunomodulatory effects of polysaccharides enzymatic hydrolysis from Hericium erinaceus on the MODE-K/DCs co-culture model. Int J Biol Macromol. 2021 Sep 30; 187:272-280.
6. H P Rang, J M Ritter, R J Flower, et al. Rang and Dale’s pharmacology, eighth edition, Elsevier, UK. 2015.
7. Delved TJ and Roitt IM. Encyclopedia of immunology, 2nd edition, Academic Press, London. 1998, 198 - 231.
8. Katzung GB. Basic and Clinical Pharmacology, twelfth edition, McGraw-Hill Companies, Inc. 2011.
9. Keyt BA, Baliga R, Sinclair AM, et al. Structure, Function, and Therapeutic Use of IgM Antibodies. Antibodies (Basel). 2020 Oct 13; 9(4): 53.