IgG4-related disease: A systematic review of a rare pediatric condition
Nội dung chính của bài viết
Tóm tắt
Immunoglobulin G4 related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder, marked by tumor-like mass-forming lesions. IgG4-RD is a recently recognized condition and has a few conducted research on the pediatric population. This study aims to provide some insights into the epidemiology, histological findings, diagnosis, and treatment of this condition in children. A systematic literature search was performed on Embase, PubMed, and Web-of-science for case reports and case series of IgG4-RD in children published between 1/2015 and 12/2023. 58 case reports and case series including 62 cases of IgG4-RD in children were identified. The mean age was 12 ± 4.4 years old, of which 54.8% were male. The orbit and central nervous system were two organs predominantly affected. Multi-organ involvement was reported in 14 cases (22.6%). Of 53 patients with serum IgG4 concentration reported, 60.4% of them had elevated serum IgG4 level. 21 patients (33.8%) had fulfilled the definitive diagnosis of the 2020 revised comprehensive diagnostic criteria. Prednisone was the first choice of treatment in 81.8% of the cases. 77.6% of the patients were treated with steroid-sparing DMARDs.
Chi tiết bài viết
Từ khóa
IgG4 related disease, pediatric, systematic review
Tài liệu tham khảo
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2. Karadeniz H, Vaglio A. IgG4-related disease: a contemporary review. Turk J Med Sci. 2020;50(SI-2):1616-1631. doi:10.3906/sag-2006-375
3. Perugino CA, Stone JH. IgG4-related disease: an update on pathophysiology and implications for clinical care. Nat Rev Rheumatol. 2020;16(12):702-714. doi:10.1038/s41584-020-0500-7
4. Ardila-Suarez O, Abril A, Gómez-Puerta JA. Enfermedad relacionada con IgG4: revisión concisa de la literatura. Reumatol Clínica. 2017;13(3):160-166. doi:10.1016/j.reuma.2016.05.009
5. Kamisawa T, Zen Y, Pillai S, et al. IgG4-related disease. The Lancet. 2015;385(9976):1460-1471. doi:10.1016/S0140-6736(14)60720-0
6. Shimizu Y, Yamamoto M, Naishiro Y, et al. Necessity of early intervention for IgG4-related disease-delayed treatment induces fibrosis progression. Rheumatology. 2013;52(4):679-683.
7. Ebbo M, Grados A, Bernit E, et al. Pathologies associated with serum IgG4 elevation. Int J Rheumatol. 2012;2012. Accessed February 15, 2024. https://www.hindawi.com/journals/ijr/2012/602809/abs/
8. Vasaitis L. IgG4-related disease: A relatively new concept for clinicians. Eur J Intern Med. 2016;27:1-9. doi:10.1016/j.ejim.2015.09.022
9. Islam AD, Selmi C, Datta-Mitra A, et al. The changing faces of IgG4-related disease: Clinical manifestations and pathogenesis. Autoimmun Rev. 2015;14(10):914-922. doi:10.1016/j.autrev.2015.06.003
10. Umehara H, Okazaki K, Kawa S, et al. The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. Mod Rheumatol. 2021;31(3):529-533. doi:10.1080/14397595.2020.1859710
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12. Goag EK, Park JE, Lee EH, et al. A case of extensive IgG4-related disease presenting as massive pleural effusion, mediastinal mass, and mesenteric lymphadenopathy in a 16-year-old male. Tuberc Respir Dis. 2015;78(4):396-400. doi:10.4046/trd.2015.78.4.396
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