Predictive value of platelet-to-albumin ratio for acute kidney injury in patients with decompensated cirrhosis: A double-center study
Nội dung chính của bài viết
Tóm tắt
This study aims to evaluate the value of the platelet-to-albumin ratio (PAR) in predicting acute kidney injury (AKI) in patients with decompensated cirrhosis. A descriptive cross-sectional analysis was conducted at multiple centers on 295 patients with decompensated cirrhosis, treated at the Department of Gastroenterology - Can Tho Central General Hospital and the Department of Gastroenterology - Bac Lieu General Hospital from June 2019 to May 2021. The results showed that the average age of the study subjects was 60.0 ± 12.5 years old, with a male/female ratio of 3/2. The average albumin level was relatively low, at 27.18 ± 6.29 g/L. The median platelet count was 73 x 109/L. The median platelet-to-albumin ratio was 2.99. The incidence of acute kidney injury in patients with decompensated cirrhosis was 33.9%. At a cut-off point of the serum platelet-to-albumin ratio ≥ 3.64, the predictive value for the incidence of acute kidney injury in patients with decompensated cirrhosis was recorded with an area under the ROC curve (AUC) of 96.7% (95%CI: 95% - 98%).
Chi tiết bài viết
Từ khóa
Platelet-to-albumin ratio, predictive value, acute kidney injury, decompensated cirrhosis
Tài liệu tham khảo
2. Nadim MK, Kellum JA, Forni L, et al. Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting. J Hepatol. 2024;81(1):163-183. doi:10.1016/j.jhep.2024.03.031.
3. Pan HC, Chien YS, Jenq CC, et al. Acute kidney injury classification for critically ill cirrhotic patients: A comparison of the KDIGO, AKIN, and RIFLE classifications. Sci Rep. 2016;6:23022. doi:10.1038/srep23022.
4. Tan J, Song G, Wang S, et al. Platelet-to-albumin ratio: A novel iga nephropathy prognosis predictor. Front Immunol. 2022;13:842362. doi: 10.3389/fimmu.2022.842362.
5. Zhai Y, Liu X, Li Y, et al. Role of platelet to albumin ratio for predicting persistent acute kidney injury in patients admitted to the intensive care unit. BMC Anesthesiol. 2023;23(1):242. doi: 10.1186/s12871-023-02137-6.
6. European Association for the Study of the Liver, European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69(2):406-460. doi: 10.1016/j.jhep.2018.03.024.
7. Duah A, Duah F, Ampofo-Boobi D, et al. Acute kidney injury in patients with liver cirrhosis: Prevalence, predictors, and in-hospital mortality at a district hospital in Ghana. Biomed Res Int. 2022;2022:4589767. doi: 10.1155/2022/4589767.
8. Angeli P, Gines P, Wong F, et al. Diagnosis and management of acute kidney injury in patients with cirrhosis: Revised consensus recommendations of the International Club of Ascites. Gut. 2015;64(4):531-537. doi: 10.1136/gutjnl-2014-30887.
9. Vo TMD. The incidence of acute kidney injury and mortality prognosis in patients with decompensated cirrhosis. Medical thesis. University of Medicine and Pharmacy at Ho Chi Minh City. 2017.
10. Ngo TYN. Study on the incidence, risk factors, treatment outcomes, and factors associated with mortality prognosis of acute kidney injury in patients with decompensated cirrhosis undergoing treatment at Can Tho Central General Hospital. Residential graduation thesis. Can Tho University of Medicine and Pharmacy. 2021.
11. Thapa P, Kc S, Hamal AB, et al. Prevalence of acute kidney injury in patients with liver cirrhosis. JNMA J Nepal Med Assoc. 2020;58(228):554-559. doi: 10.31729/jnma.5147.
12. Huang Z, Zheng Q, Yu Y, et al. Prognostic significance of platelet-to-albumin ratio in patients with esophageal squamous cell carcinoma receiving definitive radiotherapy. Sci Rep. 2022;12(1):3535. doi: 10.1038/s41598-022-07546-0.
13. Patidar KR, Xu C, Shamseddeen H, et al. Development and Validation of a Model to Predict Acute Kidney Injury in Hospitalized Patients With Cirrhosis. Clin Transl Gastroenterol. 2019;10(9):e00075. doi: 10.14309/ctg.0000000000000075.