An experimental study on the skin irritant potential of Dinh Tho patch
Nội dung chính của bài viết
Tóm tắt
Dinh Tho patches are the transdermal combination of medicinal herbs including Dracaena cambodiana Pierre ex Gagnep, Cinnamomum cassia, Kaempferia galanga, Homalomena occulta, Caesalpinia sappan, Illicium verum, Artemisia vulgaris and Reynoutria japonica with the intended indication to treat symptoms of swelling, bruising, tension and pain of the musculoskeletal system. This study was carried out to examine the skin irritation of Dinh Tho patches in experimental animals. Each individual rabbit was applied (2.5x2.5cm) Dinh Tho patch on one side of the dorsal area and (2.5x2.5cm) sodium chloride-impregnated gauze in the other size as control. The degree of erythema and edema formation were observed and scored at 1 hour, 24 hours, 48 hours and 72 hours after patch removal. Our results showed that grade 1 or grade 2 erythema only appeared 1 hour after removal of the test product. There were no signof erythema, edema or other skin injury observed after 24 hours, 48 hours or 72 hours. It can be concluded that Dinh Tho patch did not cause skin irritation in rabbits.
Chi tiết bài viết
Từ khóa
Dinh Tho patch, skin irritation, rabbits, erythema, edema
Tài liệu tham khảo
2. Barnes KA, Ball L, Desbrow B, et al. Consumption and reasons for use of dietary supplements in an Australian university population. Nutrition. 2016,32:524-530.
3. Cheng Y-C, Li TS, Su HL, et al. Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care. Molecules. 2020;25(21):5051.
4. Wang X, Wei S, Liu T, et al. Effectiveness, medication patterns, and adverse events of traditional chinese herbal patches for osteoarthritis: a systematic review. Evid Based Complement Alternat Med. 2014;343176.
5. Do Tat Loi. Vietnamese medicinal plants and herbs. Medical Publishing House; 2015.
6. Organisation for Economic Co-operation and Development. Guideline for testing of chemicals: Acute Demal Irritation/Corrotion. 2022.
7. International Organisation of Standardization. Biological evaluation of medical devices – Part 10: Tests for irritation and skin sensitization. ISO 10993-10. 2010.
8. Huynh Cong Duy, Nguyen Trung Quynh Nhu, Mai Kieu Tien, et al. Evaluating antioxidant and anti-inflammatory activities of Dracaena cambodiana Pierre ex Gagne extracts on RAW 264.7 and SW 1353 cell lines. Vietnam Journal of Science, Technology and Engineering. 2024;66(3),91-96.
9. Sun J, Liu JN, Fan B, et al. Phenolic constituents, pharmacological activities, quality control, and metabolism of Dracaena species: A review. J Ethnopharmacol. 2019;244:112138.
10. Liao JC, Deng JS, Chiu CS, et al. Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo. Evid Based Complement Alternat Med. 2012:429320.
11. JiSuk Lee, Sabina Lim. Anti-inflammatory, and anti-arthritic effects by the twigs of Cinnamomum cassia on complete Freund’s adjuvant-induced arthritis in rats. Journal of Ethnopharmacology. 2021;278:114209.
12. Vittalrao AM, Shanbhag T, Kumari M, et al. Evaluation of antiinflammatory and analgesic activities of alcoholic extract of Kaempferia galanga in rats. Indian J Physiol Pharmacol. 2011;55(1):13-24.
13. Jun-Li Yang, Trong Tuan Dao, Tran Thi Hien, et al. Further sesquiterpenoids from the rhizomes of Homalomena occulta and their anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters. 2019;29(10):1162-1167.
14. Tewtrakul S, Tungcharoen P, Sudsai T, et al. Antiinflammatory and Wound Healing Effects of Caesalpinia sappan L. Phytother Res. 2015;29(6):850-6.
15. Majali I S. Antioxidant and Anti-Inflammatory Activity of Star Anise (Illicium Verum) in Murine Model. Biomed Pharmacol J. 2022;15(2).
16. PK Ashok, Kumud Upadhyaya. Evaluation of Analgesicand Anti-inflammatory Activities of Aerial Parts of Artemisia vulgaris L. in ExperimentalAnimal Models. Journal of Biologically Active Products from Nature.2013;3:1,101-105.
17. Jo H-G, Baek CY, Lee J, et al. Inhibitory Effects of Reynoutria japonica Houtt. on Pain and Cartilage Breakdown in Osteoarthritis Based on Its Multifaceted Anti-Inflammatory Activity: An In Vivo and In Vitro Approach. International Journal of Molecular Sciences. 2024;25(19):10647.