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Published: 2025-03-26
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DOI: https://doi.org/10.52852/tcncyh.v188i3.3135
Issue
Vol. 188 No. 3 (2025)
Section
Các bài báo
How to Cite
Loan, C. T. ., Trang, N. T. Q. ., Thương, N. T. H. ., Diệp, N. T. N. ., Oanh, N. T. ., Nhung, P. H. ., Giao, V. T. Q. ., Van Doorn, H., Kesteman, T. ., Lewycka, S. ., & Bích, V. T. N. . (2025). Characterization of colistin resistance in Klebsiella pneumoniae isolated from livestock households in Nam Dinh 2023. Journal of Medical Research, 188(3), 231-239. https://doi.org/10.52852/tcncyh.v188i3.3135

Characterization of colistin resistance in Klebsiella pneumoniae isolated from livestock households in Nam Dinh 2023

Chu Thi Loan, Nguyen Thi Quynh Trang, Nguyen Thi Hong Thuong, Nguyen Thi Ngoc Diep, Nguyen Thi Oanh, Pham Hong Nhung, Vu Thi Quynh Giao, H.Rogier Van Doorn, Thomas Kesteman, Sonia Lewycka, Vu Thi Ngoc Bich

Main Article Content

Abstract

Klebsiella pneumoniae is one of the major opportunistic pathogens in humans, exhibiting resistance to multiple antibiotics and commonly found in the environment, the gastrointestinal tracts of humans and animals. The colistin resistance genes mcr-1 and mcr-3 are common variants circulating in Vietnam. However, knowledge regarding the colistin resistance profiles of community-isolated K. pneumoniae strains remains limited. This study analyzed 200 K. pneumoniae strains isolated from 150 animal fecal samples, 234 environmental samples, and 199 child fecal samples to assess colistin resistance phenotypes and the prevalence of mcr-1 and mcr-3 genes. The percentage of colistin resistance phenotypes were 22.9% (animal feces), 7.6% (environmental samples), and 0% (child feces). The MIC50 and MIC90 values of colistin were 1 µg/ml and 8 µg/ml, respectively. The proportion of K. pneumoniae harboring the mcr-1 gene was 6.5%, while 2.0% carried both mcr-1 and mcr-3, with no strain carrying only mcr-3. This study indicates that K. pneumoniae strains harboring mcr-1, mcr-3 are primarily prevalent in animal populations and the environment.

Article Details

Keywords

K. pneumoniae, colistin resistance, mcr-1, mcr-3

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