Thanh bên bài viết

PDF (English)
Đã xuất bản: 2025-05-30
Số lượt xem tóm tắt: 21
Số lượt xem PDF (English): 15
DOI: https://doi.org/10.52852/tcncyh.v190i5E16.3538
Số xuất bản
Tập 190 Số 5E16 (2025)
Chuyên mục
Các bài báo
Cách trích dẫn
Van Anh, P. T. ., Hung, B. T. ., Hai, V. X. ., Ha, N. T. ., & Duong, D. T. . (2025). Experimental evaluation of the subchronic toxicity of Phong Te Thap Ba Giang. Tạp Chí Nghiên cứu Y học, 190(5E16), 145-152. https://doi.org/10.52852/tcncyh.v190i5E16.3538

Experimental evaluation of the subchronic toxicity of Phong Te Thap Ba Giang

Pham Thi Van Anh, Bui Tien Hung, Vu Xuan Hai, Nguyen Thi Ha, Dau Thuy Duong

Nội dung chính của bài viết

Tóm tắt

Musculoskeletal disorders have become a global health burden. Phong Te Thap Ba Giang is a traditional medicine that has been used for a long time to treat various musculoskeletal disorders. This study was conducted to evaluate the subchronic toxicity of Phong te thap Ba Giang in experimental animals. Phong te thap Ba Giang was administered orally to Wistar rats at 4.32 pills/kg/day (equivalent to the recommended clinical dose) and 12.96 pills/kg/day (three times higher than the dose equivalent to the recommended clinical dose) for 12 consecutive weeks. The results showed that Phong Te Thap Ba Giang at both doses did not affect the general condition, body weight, hematological and biochemical parameters, and histological images of the liver and kidneys compared with the control group and baseline. In conclusion, Phong te thap Ba Giang did not cause subchronic toxicity in Wistar rats.

Chi tiết bài viết

Từ khóa

Phong Te Thap Ba Giang, musculoskeletal disorders, subchronic toxicity, Wistar rats

Tài liệu tham khảo

1. Cieza A, Causey K, Kamenov K, et al. Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Lond Engl. 2020;396(10267):2006-2017. doi:10.1016/S0140-6736(20)32340-0.
2. GBD. 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Lond Engl. 2018;392(10159):1789-1858. doi:10.1016/S0140-6736(18)32279-7.
3. Ministry of Health. Guidelines for diagnosis and treatment of musculoskeletal diseases. Medical Publshing House. 2016.
4. Rajalekshmi R, Agrawal DK. Therapeutic Efficacy of Medicinal Plants with Allopathic Medicine in Musculoskeletal Diseases. Int J Plant Anim Environ Sci. 2024;14(4):104-129. doi: 10.26502/ijpaes.4490170.
5. WHO. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines. 1992.
6. WHO. Working Group on the Safety and Efficacy of Herbal Medicine. 2000.
7. OECD. Guidelines for the Testing of Chemicals Repeated Dose Oral Toxicity Study in Rodents. 2008.
8. Jain B, Jain N, Jain S, et al. Exploring brucine alkaloid: A comprehensive review on pharmacology, therapeutic applications, toxicity, extraction and purification techniques. Phytomedicine Plus. 2023;3(4):100490. doi:10.1016/j.phyplu.2023.100490
9. Xue Y, Zhou S, Yang Z, et al. Angelica Sinensis Polysaccharide Inhibits Inflammation of Collagen-induced Arthritis Rat Fibroblast-like Synoviocytes by Inhibiting JAK2/STAT3 and MAPK Signaling. Arab J Chem. 2023;16(12):105320. doi:10.1016/j.arabjc.2023.105320.
10. Yang B, Yu N. Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review. Brain Res Bull. 2023;204:110800. doi:10.1016/j.brainresbull.2023.110800.
11. Bao L, Sun Y, Wang J, et al. A review of “plant gold” Eucommia ulmoides Oliv.: A medicinal and food homologous plant with economic value and prospect. Heliyon. 2024;10(2):e24851. doi:10.1016/j.heliyon.2024.e24851.
12. Fu C, Qiu Z, Huang Y, et al. Protective role of Achyranthes bidentata polysaccharides against chondrocyte extracellular matrix degeneration through lncRNA GAS5 in osteoarthritis. Exp Ther Med. 2022;24(2):532. doi:10.3892/etm.2022.11459.
13. Li Z, Ma D, Peng L, et al. Compatibility of Achyranthes bidentata components in reducing inflammatory response through Arachidonic acid pathway for treatment of Osteoarthritis. Bioengineered. 13(1):1746-1757. doi:10.1080/21655979.2021.2020394
14. Sun L, Zong SB, Li JC, et al. The essential oil from the twigs of Cinnamomum cassia Presl alleviates pain and inflammation in mice. J Ethnopharmacol. 2016;194:904-912. doi:10.1016/j.jep.2016.10.064.
15. Zhang W jin, Zhao Z yu, Chang L kun, et al. Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control. J Ethnopharmacol. 2021;266:113415. doi:10.1016/j.jep.2020.113415
16. Yang L, Hou A, Wang S, et al. A Review of the Botany, Traditional Use, Phytochemistry, Analytical Methods, Pharmacological Effects, and Toxicity of Angelicae Pubescentis Radix. Evid-Based Complement Altern Med ECAM. 2020:7460781. doi:10.1155/2020/7460781
17. Li X, Wang J, Gao L. Anti-Inflammatory and Analgesic activity of R.A.P. (Radix Angelicae Pubescentis) Ethanol Extracts. Afr J Tradit Complement Altern Med. 2013;10(3):422-426.
18. Dong L, Zhu J, Du H, et al. Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund’s Adjuvant-Induced Arthritis Rats. Evid-Based Complement Altern Med ECAM. 2017;2017:8246420. doi:10.1155/2017/8246420.