Frequency of oncologic emergencies in children with newly diagnosed cancer at the Vietnam National Children Hospital

Bui Ngoc Lan, Nguyen Thi Tinh, Vu Van An, Nguyen Thu Tuyet, Nguyen Ngoc Khoi, Anurag K. Agrawal , Hermiston L. Michelle, Le Thi Thuy Dung

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Tóm tắt

Oncologic emergencies are life-threatening complications that require urgent recognition and management in pediatric cancer patients. This study aimed to evaluate the pattern of oncologic emergencies as well as its frequency in newly diagnosed childhood cancers at Vietnam National Children’s Hospital (VNCH). From July 2019 to June 2020, 392 children aged 0 - 15 years were newly diagnosed with cancer. The median age was 3 years old, and males accounted for 58% of cases. The most common forms of cancers were acute leukemia (37.8%), neuroblastoma (19.4%), lymphoma (11.5%), and malignant brain tumors (9.9%). Oncologic emergencies were present in 19.4% of patients at diagnosis, with hematological emergencies such as severe anemia (25%) and thrombocytopenia (26%) being the most frequent, followed by respiratory failure (17%) and leukocytosis (11%). Mortality within 7 days due to oncologic emergencies was 7.9%, primarily caused by superior vena cava syndrome and tumor lysis syndrome. These findings emphasize the need for early detection and timely management of oncologic emergencies to improve treatment outcomes in pediatric cancer patients in Vietnam.

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Tài liệu tham khảo

1. Steliarova-Foucher E, Colombet M, Ries LAG, et al. International incidence of childhood cancer, 2001-10: a population-based registry study. Lancet Oncol. 2017;18(6):719-731.
2. Lewis MA, Hendrickson AW, Moynihan TJ. Oncologic emergencies: Pathophysiology, presentation, diagnosis, and treatment. CA Cancer J Clin. 2011 Sep-Oct;61(5):287-314. doi: 10.3322/caac.20124. Epub 2011 Aug 19.
3. Stephanos K, Picard L. Pediatric Oncologic Emergencies. Emerg Med Clin North Am. 2018;36(3):527-535. doi: 10.1016/j.emc.2018.04.007.
4. Prusakowski MK, Cannone D. Pediatric Oncologic Emergencies. Hematol Oncol Clin North Am. 2017;31(6):959-980. DOI: 10.1016/j.hoc.2017.08.003.
5. Hastings CA, Torkildson JC, Agrawal AK. Handbook of Pediatric Hematology and Oncology. 2nd edition. 2012. Chapter 13: 133-143. Wiley-Blackwell.
6. Çiftçi AÇ, Kupeli S, Sezgin G, et al. Evaluation of pediatric patients with an oncologic emergency: Single center experience. Turk J Pediatr. 2018;60(6):660-668. DOI: 10.24953/turkjped.2018.06.006.
7. Leung KKY, Hon KL, Hui WF, et al. Therapeutics for paediatric oncological emergencies. Drugs Context. 2021 Jun 23;10:2020-11-5. doi: 10.7573/dic.2020-11-5. PMID: 34234831; PMCID: PMC8232653.
8. Yang QS, Han YL, Cai JY, et al. Analysis of 42 cases of childhood superior vena cava syndrome associated with mediastinal malignancy. Zhonghua Er Ke Za Zhi. 2022;60(10):1026-1030. DOI: 10.3760/cma.j.cn112140-20220323-00239
9. Ozcan A, Unal E, Karakukcu M, et al. Vena cava superior syndrome in the children with mediastinal tumors: Single-center experience. North Clin Istanb. 2020;7(3):255-259. DOI: 10.14744/nci.2019.46354
10. Quraishi NA, Palliyil N, Hassanin MA, et al. Malignant spinal cord compression in the paediatric population-a systematic review, meta-analysis. Eur Spine J. 2023;32(12):4306-4313. DOI: 10.1007/s00586-023-07820-3
11. De Martino L, Spennato P, Vetrella S, et al. Symptomatic malignant spinal cord compression in children: a single-center experience. Ital J Pediatr. 2019;45(1):80. DOI: 10.1186/s13052-019-0671-5.
12. Calle MG, Valdez SG, Quiroz EG. Characteristics of tumor lysis syndrome in pediatric oncology patients. A single-center observational study. Oncología (Ecuador). 2023:33(3). 228-238, DOI: 10.33821/728.
13. Saeed F, Ali MS, Ashraf MS, et al. Tumour lysis syndrome in children with haematological cancers: Experience at a tertiary care hospital in Karachi. J Pak Med Assoc. 2018;68(11):1625-1630.
14. Howard SC, Jones DP, Pui C-H. The Tumor lysis syndrome. N Engl J Med. 2011;364:1844-54. doi: 10.1056/NEJMra0904 569.