Total phenolic content, flavonoid content, and antihyperlipidemic activity of “Che pham la Bo” extract in poloxamer-407-induced experimental hyperlipidemia

Tóm tắt

The leaves of the avocado tree (Persea americana) have been used in folk medicine in many parts of the world, particularly in South America, Africa, and Asia, due to their potential medicinal properties. This research was conducted to investigate total phenolic and flavonoid content, and the potential ameliorating effects of “Che pham la Bo” (CPLB) extract on hyperlipidemic experimental mice. To identify the content of the active compound, spectroscopy techniques are used. The endogenous hyperlipidemia model was induced by an intraperitoneal (i.p.) injection of Poloxamer-407 (200 mg/kg body weight), and CPLB extract was administered orally to mice at daily doses of 0.48 g/kg and 1.44 g/kg body weight for seven consecutive days. At the end of the study, parameters of serum lipids were determined. The results show that the methanol extract of P.americana resulted in the greatest phenolic and flavonoid content. CPLB ameliorated the elevation of serum triglyceride levels at both doses of 0.48 g/kg body weight and 1.44 g/kg body weight.w/ Also, there was no significant difference in the increase in high-density lipoprotein cholesterol levels and reduced total cholesterol, Non-high-density lipoprotein cholesterol compared to the cholesterol control group. In conclusion, CPLB extract improved serum lipid levels in the P407-induced hyperlipidemia model.