Repeated-dose 90-day oral toxicity study of picositol in experimental Wistar rats
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Tóm tắt
This study aimed to evaluate the subchronic toxicity of Picositol powder following oral administration in Wistar rats. The experiment was conducted in accordance with the guidelines of the Organization for Economic Co-operation and Development (OECD 408). Rats were administered Picositol at two doses of 0.12 sachets/kg/day and 0.36 sachets/kg/day by oral gavage for 90 consecutive days. Measurements included body weight, general observations, hematology, biochemical, gross necropsy, and histopathological examination. The results show that oral administration of both doses of Picositol to rats did not result in any clinical symptom, nor hematological, biochemical, and histological signs of variation. In conclusion, a 90-days repeated dose oral toxicity study of Picositol in Wistar rats yielded no-observed-adverse-effect at 0.12 sachets/kg/day and 0.36 sachets/kg/day.
Chi tiết bài viết
Từ khóa
Picositol, repeated dose toxicity, Wistar rats
Tài liệu tham khảo
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