Acute and chronic anti-inflammatory effects of Mekong Cissus capsules in experimental animals
Nội dung chính của bài viết
Tóm tắt
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells, and toxic compounds. These factors may induce acute and/or chronic inflammatory responses leading to tissue damage or disease. Current anti-inflammatory drug groups have not met treatment effectiveness and cause many unwanted side effects for patients. Therefore, this study was conducted to evaluate the anti-inflammatory effect of Mekong Cissus capsules in an experimental study. Before carrageenin-induced acute edema, Wistar rats were randomly divided into four groups (normal, positive control, Mekong Cissus capsules 168 and 504 mg/kg/24h) and given water/test solution for five consecutive days. The results showed that Mekong Cissus capsules at 504 mg/kg/24h had the effect of reducing the volume of peritoneal exudate and the number of leukocytes in the fluid after injection of a mixture of carrageenin and formaldehyde, similar to aspirin, and also tended to reduce the volume of carrageenin-induced mouse paw edema. However, Mekong Cissus capsules have not shown any effect against chronic inflammation caused by asbestos in Swiss mice. This study demonstrated the potential in vivo efficacy of Mekong Cissus capsules in the treatment of inflammatory diseases as a promising therapeutic product.
Chi tiết bài viết
Từ khóa
Mekong Cissus capsules, acute anti-inflammatory effects, chronic anti-inflammatory effects, herbal medicine, Wistar rats, Swiss mice
Tài liệu tham khảo
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