Evaluation of the anticoagulant effect of Saphia Alkali K90 in an experimental thrombosis model
Nội dung chính của bài viết
Tóm tắt
The study aimed to investigate the anticoagulant effects of Saphia Alkali K90 in a rat model of lipopolysaccharide-induced thrombosis. Saphia Alkali K90 and rivaroxaban were administered orally for seven consecutive days. Two hours after the final administration, LPS (3 mg/kg) was injected via the tail vein to induce thrombotic changes. Blood samples were collected four hours later to assess coagulation. The results showed that Saphia Alkali K90 at 54 ml/kg/day produced a significant anticoagulant effect, evidenced by increased platelet count and fibrinogen concentration, as well as a significant prolongation of the activated partial thromboplastin time compared to the vehicle-treated group (p < 0.05). In contrast, Saphia Alkali K90 at 27 ml/kg/day showed a non-significant tendency toward similar changes (p > 0.05). In conclusion, SAK90 at 54 ml/kg/day exerted an anticoagulant effect in rats with LPS-induced thrombosis.
Chi tiết bài viết
Từ khóa
Saphia Alkali K90, anticoagulant effect, lipopolysaccharide, Wistar rats
Tài liệu tham khảo
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