Evaluation of the anti-fatigue effects of NSDVT extract in experimental animals
Nội dung chính của bài viết
Tóm tắt
Chronic fatigue syndrome (CFS) is characterized by persistent or recurrent fatigue, cognitive dysfunction, impaired physical performance, and a reduced ability to perform daily activities, with symptoms that do not improve after rest. NSDVT extract is a traditional herbal formulation composed of Radix Ginseng, Radix Paeoniae Lactiflorae, Radix Angelicae Sinensis, Radix Rehmanniae Praeparata, Radix Astragali Membranacei, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Glycyrrhizae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Polygalae, Fructus Schisandrae, Rhizoma Zingiberis, and Fructus Ziziphi Jujubae. This formulation has long been used in traditional medicine to tonify Qi and blood, nourish the heart, and calm the mind. In this study, we evaluated the anti-fatigue effects of NSDVT extract in Swiss albino mice. NSDVT extract administered orally at 2.5 and 5 g/kg significantly increased forelimb grip strength and prolonged swimming endurance in a time- and dose-dependent manner, with superior persistence of effect compared to sulbutiamine. In addition, NSDVT extract showed a tendency to increase blood glucose levels, total serum protein concentration, and red blood cell count after two weeks of administration. These findings suggest that NSDVT extract possesses significant anti-fatigue properties and may serve as a promising natural therapeutic option for the management of chronic fatigue syndrome.
Chi tiết bài viết
Từ khóa
Chronic fatigue syndrome, traditional medicine, herbal formulation, anti-fatigue activity, mice
Tài liệu tham khảo
2. Wallis A, Ball M, McKechnie S, Butt H, Lewis DP, Bruck D. Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and D-lactic acidosis: a systematic review. J Transl Med. 2017; 15(1): 129. doi:10.1186/s12967-017-1229-1.
3. Vermeulen RCW, Kurk RM, Visser FC, Sluiter W, Scholte HR. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med. 2010; 8: 93. doi:10.1186/1479-5876-8-93.
4. Jason LA, Richman JA, Rademaker AW, et al. A community-based study of chronic fatigue syndrome. Arch Intern Med. 1999; 159(18): 2129-2137. doi:10.1001/archinte.159.18.2129.
5. Ratan ZA, Youn SH, Kwak YS, et al. Adaptogenic effects of Panax ginseng on modulation of immune functions. J Ginseng Res. 2021; 45(1): 32-40. doi:10.1016/j.jgr.2020.09.004.
6. Jia J, Chen J, Wang G, Li M, Zheng Q, Li D. Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix. Biomed Pharmacother Biomedecine Pharmacother. 2023; 168: 115809. doi:10.1016/j.biopha.2023.115809.
7. Gong W, Zhu S, Chen C, et al. The Anti-depression Effect of Angelicae Sinensis Radix Is Related to the Pharmacological Activity of Modulating the Hematological Anomalies. Front Pharmacol. 2019; 10. doi:10.3389/fphar.2019.00192.
8. Yang M, Dai Y, Qin X. The neuroprotective effects and related mechanisms of paeoniflorin on nervous system diseases: a review. Adv Tradit Med. Published online December 15, 2025. doi:10.1007/s13596-025-00876-0.
9. Kang JY, Kim DY, Lee JS, et al. Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model. Nutrients. 2021; 13(9): 3121. doi:10.3390/nu13093121.
10. Lee JC, Kao JY, Kuo DH, et al. Antifatigue and Antioxidant Activity of Alcoholic Extract from Saussurea involucrata. J Tradit Complement Med. 2011; 1(1): 64-68. doi:10.1016/s2225-4110(16)30058-x.
11. Mai Phuong Thanh, Tran Thanh Tung, Pham Chi Phuong. Tác dụng chống mệt mỏi và mức độ an thần của nước Kiện Lực Hồng Mã ít đường trên thực nghiệm. Tạp chí Nghiên cứu Y học. 182 (9). 2024. 208-218.
12. Van Reeth O. Pharmacologic and therapeutic features of sulbutiamine. Drugs Today Barc Spain 1998. 1999; 35(3): 187-192. doi:10.1358/dot.1999.35.3.533848.
13. Chen YJ, Baskaran R, Shibu MA, Lin WT. Anti-Fatigue and Exercise Performance Improvement Effect of Glossogyne tenuifolia Extract in Mice. Nutrients. 2022; 14(5): 1011. doi:10.3390/nu14051011.
14. Liu Y, Liu C. Antifatigue and increasing exercise performance of Actinidia arguta crude alkaloids in mice. J Food Drug Anal. 2016; 24(4): 738-745. doi:10.1016/j.jfda.2016.03.001.
15. Mairbäurl H. Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells. Front Physiol. 2013; 4: 332. doi:10.3389/fphys.2013.00332.
16. Zhao X, Cui Y, Wu P, et al. Polygalae Radix: A review of its traditional uses, phytochemistry, pharmacology, toxicology, and pharmacokinetics. Fitoterapia. 2020; 147: 104759. doi:10.1016/j.fitote.2020.104759.
17. Zhou S, Haoxiang C, Chensi G, Tingting W, Ziluan F. Evaluation of Schisandra chinensis extract on anti-fatigue activity in mice. Food Biosci. 2023; 56: 103129. doi:10.1016/j.fbio.2023.103129.
18. An updated review of Ziziphus jujube: Major focus on its phytochemicals and pharmacological properties. Pharmacol Res - Mod Chin Med. 2023; 8: 100297. doi:10.1016/j.prmcm.2023.100297.
19. Luo W, Zhang K, Wang Y, et al. The Rhizome of Atractylodes macrocephala Koidz.: A Comprehensive Review on the Traditional Uses, Phytochemistry and Pharmacology. Chem Biodivers. 2025; 22(3): e202401879. doi:10.1002/cbdv.202401879.
20. Gao X, Wang W, Wei S, Li W. [Review of pharmacological effects of Glycyrrhiza radix and its bioactive compounds]. Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J Chin Mater Medica. 2009; 34(21): 2695-2700.
21. Phytochemical and pharmacological studies on Radix Angelica sinensis. Chin J Nat Med. 2013; 11(6): 577-587. doi:10.1016/S1875-5364(13)60067-9.
22. Zhang X, Jiang Y, Zeng J, et al. Phytochemistry, pharmacological properties and pharmacokinetics of Citri Reticulatae Pericarpium: A systematic review. J Ethnopharmacol. 2024; 333: 118503. doi:10.1016/j.jep.2024.118503.
23. Li X, Ao M, Zhang C, Fan S, Chen Z, Yu L. Zingiberis Rhizoma Recens: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Toxicology. Evid-Based Complement Altern Med ECAM. 2021; 2021: 6668990. doi:10.1155/2021/6668990.