Current evidence on FLG, IL4Rα and CLDN-1 genetic variants in atopic dermatitis in the Vietnamese population: A review study

Tóm tắt

This narrative review was conducted to summarize the currently available evidence on FLG, IL4Rα and CLDN1 genetic variants in atopic dermatitis in the Vietnamese population, based on studies published between 2019 and 2025. The review focused on genotype distribution, allele frequencies and reported associations between genetic variants and clinical characteristics. Available evidence suggests that skin barrier-related genes, particularly FLG and CLDN1, may be associated with epidermal barrier dysfunction, disease severity and family history. The spectrum of FLG variants in the Vietnamese population also appears to be genetically diverse. For IL4Rα, the variants rs1801275 and rs1805010 have not shown a clear association with disease susceptibility, but may be related to disease severity as measured by the SCORAD index and to age of onset. Overall, current findings provide preliminary evidence that genetic factors may contribute to the clinical heterogeneity of atopic dermatitis in the Vietnamese population.