Clinical outcomes of modified widman flap surgery with and without adjunctive emdogain in anterior maxillary periodontitis: Randomized split-mouth clinical trial

Tóm tắt

Modified Widman flap is a well-established surgical treatment for advanced periodontitis. However, its regenerative potential remains limited, prompting the adjunctive use of Emdogain to improve clinical outcomes. This randomized split-mouth clinical trial evaluated the adjunctive use of Emdogain in anterior maxillary periodontitis at Ho Chi Minh City Odonto-Stomatology Hospital from July 2025 to March 2026. A total of 34 patients with 128 maxillary anterior teeth were included, with comparable baseline probing pocket depth (PPD) and clinical attachment level (CAL) between groups. At 1 month, both parameters were significantly reduced in the Emdogain group (p < 0.001). At 3 months, Emdogain achieved greater mean PPD (3.68 ± 0.64 mm vs 4.52 ± 0.72 mm) and CAL (4.08 ± 0.68 mm vs 4.52 ± 0.72 mm), with p < 0.001. Pocket closure was more frequent in the Emdogain group at both 1 and 3 months. Plaque index (PI) and gingival index (GI) improved significantly in both groups without significant between-group differences. Pain on day 7 was lower in the Emdogain group, and the proportion of good outcomes at 3 months was higher (76.2% vs 52.4%, p = 0.020). In conclusion, adjunctive Emdogain provided additional some clinical benefits when used in conjunction with modified Widman flap surgery in patients with anterior maxillary periodontitis in short-term.