An assessment of acute and subchronic toxicity of Gas Anta Syrup in rodents
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Tóm tắt
Gas Anta Syrup is a formulation derived from herbal ingredients, intended for the supportive treatment of peptic ulcers and gastroesophageal reflux disease. This study was conducted to evaluate the acute and subchronic toxicity of Gas Anta Syrup in Swiss mice. In the acute toxicity test, mice were administered increasing doses of the syrup to determine the minimum dose causing 100% mortality and the maximum dose causing 0% mortality. In the subchronic toxicity study, mice were divided into a control group and two treatment groups receiving the syrup at 4.32 and 12.96 mL/kg/day for 4 weeks. Parameters monitored included general conditions, body weight, hematological and biochemical indices, as well as gross and microscopic examinations of the liver and kidneys. Results indicated that at the maximum feasible dose of 100 mL/kg, no toxic manifestation or mortality was observed in the acute toxicity study. No significant difference was observed in the monitored indices between the treatment groups and the control group in the subchronic toxicity study. In conclusion, Gas Anta Syrup does not induce acute or subchronic toxicity in Swiss mice at the tested dosage levels.
Chi tiết bài viết
Từ khóa
Gas Anta Syrup, peptic ulcers, gastroesophageal reflux disease, acute toxicity, subchronic toxicity, Swiss mice
Tài liệu tham khảo
2. Wickramasinghe N, Devanarayana N. Insight into global burden of gastroesophageal reflux disease: Understanding its reach and impact. World J Gastrointest Pharmacol Ther. 2025; 16(1). doi:10.4292/wjgpt.v16.i1.97918.
3. Bhatnagar MS, Choudhari S, Pawar D, Sharma A. Long-Term Use of Proton-Pump Inhibitors: Unravelling the Safety Puzzle. Cureus. 2024; 16(1): e52773. Published 2024 Jan 23. doi:10.7759/cureus.52773.
4. Kuna L, Jakab J, Smolic R, Raguz-Lucic N, Vcev A, Smolic M. Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options. J Clin Med. 2019; 8(2): 179. Published 2019 Feb 3. doi:10.3390/jcm8020179.
5. Loi DT. Medicinal Plants and Ingredients of Vietnam. Hanoi: Science and Technology Publishing House; 1991.
6. Gerhard Vogel H. Drug discovery and evaluation Pharmacological assays. Springer. 2016.
7. World Health Organization. Working group on the safety and efficacy of herbal medicine. Report of regional office for the western pacific of the World Health Organization. 2013.
8. Burdock, George & Chatzidakis, Chris. Safety Assessment of Panax Ginseng. Int J Toxicol. 2000; 19(4). 293-301. doi: 10.1080/10915810050202105.
9. Ning N, Wang YZ, Zou ZY, Zhang DZ, Wang DZ, Li XG. Pharmacological and safety evaluation of fibrous root of Rhizoma Coptidis. Environ Toxicol Pharmacol. 2015 Jan; 39(1): 53-69. doi: 10.1016/j.etap.2014.11.006.
10. Khalid AS, Momodu I, Iduh MU, Sirajo BS, Khalid HS, Wasagu HI. Toxicity assessment of ethanol extract of Saussurea lappa (costus) root in male Wistar rats. Afr J Biol Med Res. 2024; 7(4): 79-89. doi:10.52589/AJBMR-0ICVBWCK.
11. Wang B, Wu C, Ma Y, et al. Recent advances in Bletilla striata polysaccharide research: extraction methodologies, structural elucidation, pharmacological mechanisms, structure-activity relationships, and therapeutic delivery applications. Front Pharmacol. 2025; 16: 1688676. Published 2025 Nov 5. doi:10.3389/fphar.2025.1688676.
12. Lee YH, Kim D, Lee MJ, Kim MJ, Jang HS, Park SH, Lee JM, Lee HY, Han BS, Son WC, Seok JH, Lee JK, Jeong J, Kang JS, Kang JK. Subchronic toxicity study of Coptidis Rhizoma in rats. J Ethnopharmacol. 2014; 152(3): 457-463. doi:10.1016/j.jep.2014.01.011.
13. Han SR, Han HY, Park HJ, Mi BS, Chung MK, Moon KS, Jeong JY, Roh HS, Seok JH, Kim SK. Toxicity assessment of Cyperi rhizoma aqueous extract orally administered to rats for 13 consecutive weeks. Yakhak Hoeji. 2013; 57(4): 258-264.