Nội dung chính của bài viết
Phong thap dan tablets are intended to treat low back pain. This study was carried out to evaluate the
analgesic effects of Phong thap dan tablets in experimental animals. The analgesic effects were evaluated in
three animal models: hot plate, mechanical stimulation and acetic acid-induced writhing test. Mice were divided
into 4 groups given oral water, control drug (codein phosphate in hot plate and mechanical stimulation tests or
aspirin in writhing test), Phong thap dan at 2.88 tablets (1.44 g) or 8.64 tablets (4.32 g)/kg b.w/day, respectively.
Our results showed that Phong thap dan tablets at both doses increased the reaction time to thermal stimulation,
increased the paw withdrawal latency and the force required to elicit a paw withdrawal and decreased the
number of acetic acid-induced writhing movements in mice. There was no statistically significant difference
between 2 doses of Phong thap dan tablets in three animal models. We conclude that Phong thap dan tablets
at the doses of 2.88 tablets and 8.64 tablets/kg b.w/day showed significant analgesic effect in animal models.
Chi tiết bài viết
Phong thap dan tablets, analgesic, mice, hot plate, mechanical stimulation, writhing test
Tài liệu tham khảo
Diseases And Injuries, 1990-2015: A Systematic Analysis For The Global Burden Of Disease Study 2015.
2. Bart W. Koes, Maurits van Tulder and S.Thomas. Diagnosis and treatment of low back pain. BMJ. 2006;332(7555):1430-4.
3. Turner R. R. A. (Ed.). Turner Screening Methods in Pharmacology. Academic Press, London. 1965;100.
4. Qnais E, Bseiso Y, Wedyan M, Alkhateeb H. Evaluation of Analgesic Activity of the Methanol Extract from the Leaves of Arum Palaestinum in Mice and Rats. Biomed Pharmacol J. 2017;10(3).
5. Deuis JR, Dvorakova LS, Vetter I. Methods Used to Evaluate Pain Behaviors in Rodents. Front Mol Neurosci. 2017;10:284.
6. Lu R., Schmidtko A. Direct intrathecal drug delivery in mice for detecting in vivo effects of cGMP on pain processing. Methods Mol. Biol. 2013;1020:215-221.
7. Shojaii A, Motaghinejad M, Norouzi S, Motevalian M. Evaluation of Anti-inflammatory and Analgesic Activity of the Extract and Fractions of Astragalus hamosus in Animal Models. Iran J Pharm Res. 2015;14(1):263-269.
8. Zhang Z, Shi L. Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori. Fitoterapia. 2010 Apr;81(3):214-8.
9. Manirujjaman, Farhana Sultana, Imran-Ul-Haque et al. Page In Vivo Assay of Analgesic Activity of Methanolic and Petroleum Ether Extracts of Vitex Negundo Leaves. Journal of Pharmacy and Biological Sciences. 2013;volume 7,issue 2;56-59.
10. Li X, Wang J, Gao L. Anti-inflammatory and analgesic activity of R.A.P. (Radix Angelicae Pubescentis) ethanol extracts. Afr J Tradit Complement Altern Med. 2013;10(3):422-426.