1. Clinical and preclinical characteristics of neonates with congenital syphilis in the national center of vietnam National Children’s hospital
Nội dung chính của bài viết
This prospective observational study was conducted to investigate epidemiological and clinical features of neonates with congenital syphilis at the Neonatal Center of Vietnam National Children’s Hospital from January 2018 to June 2021. Twenty-nine patients were diagnosed with congenital syphilis by Treponema Pallidum hemagglutination assay (TPHA) reaction. The most common manifestations of congenital syphilis were desquamation (41.4%), hepatomegaly (31.4%), splenomegaly (37.9%), and early jaundice (24.1%). Thrombocytopenia, anemia, elevated liver enzymes, and conjugated hyperbilirubinemia were common laboratory findings of congenital syphilis. The mortality rate of congenital syphilis was 13.7%. Parental syphilis status of 51.9% of neonates born with congenital syphilis was unknown. Thus, a systematic launch of a screening program for syphilis for all pregnant women is critical.
Chi tiết bài viết
Congenital infection, syphilis, neonate
Tài liệu tham khảo
2. Kimball A, Torrone E, Miele K, et al. Missed Opportunities for Prevention of Congenital Syphilis - United States, 2018. MMWR Morb Mortal Wkly Rep. 2020; 69(22): 661-665. doi:10.15585/mmwr.mm6922a1.
3. Hussain SA, Vaidya R. Congenital Syphilis. In: StatPearls. StatPearls Publishing; 2022. Accessed March 26, 2022. http://www.ncbi.nlm.nih.gov/books/NBK537087/.
4. Galvis AE, Arrieta A. Congenital Syphilis: A U.S. Perspective. Children. 2020; 7(11): 203. doi:10.3390/children7110203.
5. Lawn JE, Blencowe H, Waiswa P, et al. Stillbirths: rates, risk factors, and acceleration towards 2030. Lancet Lond Engl. 2016; 387(10018): 587-603. doi:10.1016/S0140-6736(15)00837-5.
6. Oloya S, Lyczkowski D, Orikiriza P, et al. Prevalence, associated factors and clinical features of congenital syphilis among newborns in Mbarara hospital, Uganda. BMC Pregnancy Childbirth. 2020; 20: 385. doi:10.1186/s12884-020-03047-y.
7. Zhou Q, Wang L, Chen C, Cao Y, Yan W, Zhou W. A Case Series of 130 Neonates with Congenital Syphilis: Preterm Neonates Had More Clinical Evidences of Infection than Term Neonates. Neonatology. 2012; 102(2): 152-156. doi:10.1159/000339291.
8. Lawi JD, Mirambo MM, Magoma M, et al. Sero-conversion rate of Syphilis and HIV among pregnant women attending antenatal clinic in Tanzania: a need for re-screening at delivery. BMC Pregnancy Childbirth. 2015;15:3. doi:10.1186/s12884-015-0434-2.
9. Lago EG, Vaccari A, Fiori RM. Clinical features and follow-up of congenital syphilis. Sex Transm Dis. 2013; 40(2): 85-94. doi:10.1097/OLQ.0b013e31827bd688.
10. Yarali N, Balaban I, Akyurek N, Ucar S, Zorlu P. Hemophagocytosis: the cause of anemia and thrombocytopenia in congenital syphilis. Pediatr Hematol Oncol. 2009; 26(6): 461-466. doi:10.3109/08880010903091897.
11. Cifuentes C Y, Vallejo R C. Anicteric Hepatitis as Congenital Syphilis Manifestation. Infectio. 2013; 17(3): 163-166.
12. Yang H, Zhang H, Wang C, Pang L. An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis. BMC Pediatr. 2021; 21(1): 498. doi:10.1186/s12887-021-02932-5.
13. Gupta K, Bhardwaj A, Dash S, Kaur IR. Role of Treponema pallidum hemagglutination assay for diagnosis of syphilis in low titers of VDRL-reactive sera: A prospective study from a large tertiary care center of East Delhi. J Fam Med Prim Care. 2018;7(6):1594. doi:10.4103/jfmpc.jfmpc_258_18.