17. Evaluation of the protective effect of agar-hp hard capsule for peptic ulcer in experimental animals

Dang Thi Thu Hien1, Dinh Thi Thu Trang, Do Linh Quyen, Nguyen Thi Thu Ha, Huynh Nguyen Loc, Dinh Thi Lan Huong, Truong Thi Ngoc Lan, Truong Do Anh Huy, Pham Thi Van Anh
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Tóm tắt

Imbalance between exogenous damaging agents and protective factors in the gastro-duodenum tract can lead to peptic ulcer disease. Herbal medicines could be an effective treatment to human gastric ulcers. This study aimed to investigate the protective effect of AGAR-HP hard capsules on cysteamine-induced gastric-duodenal ulcers in experimental rats. The animals were divided into five treatment groups: Group 1 (control) and group 2 (model) were treated with distilled water, group 3 received esomeprazole at 10 mg/kg, group 4 received AGAR-HP at 0.074 g/kg, and group 5 received AGAR-HP at 0.221 g/kg. All the rats were treated for seven consecutive days. On day 7, peptic-duodenal ulcer were induced by oral cysteamine 400 mg/kg. The number of rats with the ulcer, the number of ulcers per rat, and the ulcer index of each group were recorded. Compared to group 2, AGAR-HP at high dose reduced the mean number of ulcers and the ulcer index under macroscopic and microscopic examinations. These parameters also decreased in the group of AGAR-HP low doses compared to the cysteamine control group. AGAR-HP hard capsules showed some protective effect on cysteamine-induced gastric ulcers in experimental rats.

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Tài liệu tham khảo

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