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Published: 2023-03-14
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DOI: https://doi.org/10.52852/tcncyh.v161i12E11.1181
Issue
Vol. 161 No. 12E11 (2022): Volume 161 E11 (12)
Section
Các bài báo
How to Cite
Hien, D. T. T. ., Trang, D. T. T., Quyen, D. L. . . . . . . . . . . . . . ., Ha, N. T. T. . . . . ., Loc, H. N. . . . . . . ., Huong, D. T. L., Lan, T. T. N., Huy, T. D. A., & Anh , P. T. V. (2023). 17. Evaluation of the protective effect of agar-hp hard capsule for peptic ulcer in experimental animals. Journal of Medical Research, 161(12E11), 135-142. https://doi.org/10.52852/tcncyh.v161i12E11.1181 (Original work published December 28, 2022)

17. Evaluation of the protective effect of agar-hp hard capsule for peptic ulcer in experimental animals

Dang Thi Thu Hien1, Dinh Thi Thu Trang2, Do Linh Quyen3, Nguyen Thi Thu Ha4, Huynh Nguyen Loc, Dinh Thi Lan Huong5, Truong Thi Ngoc Lan5, Truong Do Anh Huy5, Pham Thi Van Anh 4
1 Bộ môn Dược lý
2 Hospital 74
3 Vietnam National University – University of Medicine and Pharmacy
4 Hanoi Medical University
5 Traditional Medicine Institute of Ho Chi Minh city.

Main Article Content

Abstract

Imbalance between exogenous damaging agents and protective factors in the gastro-duodenum tract can lead to peptic ulcer disease. Herbal medicines could be an effective treatment to human gastric ulcers. This study aimed to investigate the protective effect of AGAR-HP hard capsules on cysteamine-induced gastric-duodenal ulcers in experimental rats. The animals were divided into five treatment groups: Group 1 (control) and group 2 (model) were treated with distilled water, group 3 received esomeprazole at 10 mg/kg, group 4 received AGAR-HP at 0.074 g/kg, and group 5 received AGAR-HP at 0.221 g/kg. All the rats were treated for seven consecutive days. On day 7, peptic-duodenal ulcer were induced by oral cysteamine 400 mg/kg. The number of rats with the ulcer, the number of ulcers per rat, and the ulcer index of each group were recorded. Compared to group 2, AGAR-HP at high dose reduced the mean number of ulcers and the ulcer index under macroscopic and microscopic examinations. These parameters also decreased in the group of AGAR-HP low doses compared to the cysteamine control group. AGAR-HP hard capsules showed some protective effect on cysteamine-induced gastric ulcers in experimental rats.

Article Details

Keywords

AGAR-HP, peptic ulcer, experimental animals

References

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