21. Evaluation of anti-hemorrhoidal activity of “Tri 01” hard capsule on experimental model of hemorrhoids in wistar in rats

Tran Dang Trung, Nguyen Thi Thu Ha, Nguyen Thi Thanh Loan, Pham Thi Van Anh

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Tóm tắt

This study evaluated the anti-hemorrhoidal effect of “TRI 01” hard capsule on croton oil-induced hemorrhoids model in rats. Hemorrhoids were induced by applying 6% croton oil preparation in the ano-rectal region. Then, rats were randomly assigned to groups. For the two “TRI 01” groups, “TRI 01” was orally administered at doses of 2.64 and 7.92 g/kg per day for seven days, respectively. Daflon (360 mg/kg per day) was used as reference anti-hemorrhoidal drug. Weighting of ano-rectal tissue, calculation of ano-rectal coefficient, and histology of ano-rectal tissue were conducted two hours after the last administration on the seventh day. The results indicated that treatment using “TRI 01” hard capsule significantly decreased the weight of ano-rectal tissue and the rectoanal coefficient compared to the vehicle-treated hemorrhoid group. Histological observation revealed that TRI 01-treated animals had lesser degree of inflammatory cells, degenerative changes congestion, edema along with lesser degree of necrosis in the mucosal epithelium of ano-rectal tissue as compared to croton-induced hemorrhoid group. Our study demonstrated that “TRI 01” at doses of 2.64 and 7.92 g/kg had anti-hemorrhoidal activity on croton oil-induced hemorrhoids model in rats.

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