Thanh bên bài viết

PDF (English)
Đã xuất bản: 2023-12-31
Số lượt xem tóm tắt: 51
Số lượt xem PDF (English): 52
DOI: https://doi.org/10.52852/tcncyh.v173i12E13.1898
Số xuất bản
Tập 173 Số 12E13 (2023)
Chuyên mục
Các bài báo
Cách trích dẫn
Anh, P. T. V., Duong, D. T., Thang, N. H., Lien, N. T. H., Van, N. T. H., & Thanh, M. P. (2023). 6. Genotoxic evaluation of kovir capsules using mammalian bone marrow chromosomal aberration test. Tạp Chí Nghiên cứu Y học, 173(12E13), 47-53. https://doi.org/10.52852/tcncyh.v173i12E13.1898

6. Genotoxic evaluation of kovir capsules using mammalian bone marrow chromosomal aberration test

Pham Thi Van Anh, Dau Thuy Duong, Nguyen Huu Thang, Nguyen Thi Huong Lien, Nguyen Thi Hong Van, Mai Phuong Thanh

Nội dung chính của bài viết

Tóm tắt

The genotoxic potential of KOVIR capsules was investigated in vivo using the mammalian bone marrow chromosomal aberration test. Four groups of mice, seven in each group, were used in the study: Group I served as vehicle control; Group II received the positive control (cyclophosphamide 50 mg/kg; single dose; intraperitoneal route); and Group III to IV were given orally the KOVIR capsules, suspended in distilled water, at a single test dose of 2.16 and 4.32 capsules/kg, respectively. The obtained data disclosed the safety of KOVIR capsules, which did not show substantial genotoxic effects at either dose when compared with the vehicle group.

Chi tiết bài viết

Từ khóa

KOVIR, bone marrow, chromosome aberration, mice

Tài liệu tham khảo

1. Jain P, Darji P, Thakur BS, et al. Immunostimulants: Concepts, Types and Functions. Asian Journal of Dental and Health Sciences. 2022; 2:26-34.
2. Mitra S, Paul S, Roy S, Sutradhar H, Bin Emran T, et al. Exploring the Immune-Boosting Functions of Vitamins and Minerals as Nutritional Food Bioactive Compounds: A Comprehensive Review. Molecules. 2022; 27(2): 555. doi: 10.3390/molecules27020555.
3. Dinh Thi Thu Hang. Evaluation of toxicity and immunostimulating effects of Kovir capsules on experimental animals. Resident Doctor’s Thesis, Hanoi Medical University. 2017. [Vietnamese].
4. World Health Organization & Food and Agriculture Organization of the United Nations. Section 4.5: Genotoxicity (Updated in 2020), Chapter 4: Hazard Identification and Characterization; Toxicological and Human Studies. In: Principles and methods for the risk assessment of chemicals in food (Environmental health criteria; 240). 2009.
5. Hoffmann GR. Mutagenicity testing in environmental toxicology. Environ Sci Technol. 1982; 16(10):560A-574A.
6. ILAR. Guide for the Care and Use of Laboratory Animals (8th edition). National Research Council, Institute of Laboratory Animal Resources, National Academy Press, Washington, DC. 2011.
7. Organization for Economic Cooperation and Development (OECD). Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test. OECD Publishing, Paris. 2014.
8. Majeed M, Natarajan S, Bani S, Pandey A, Neupane P. Mutagenic, Genotoxic and Sub Chronic Oral Safety Analysis of Boswellia Serrata Extract (Boswellin® Super). International Journal of Research Studies in Medical and Health Sciences. 2020; 5(7): 20-32.
9. Ahmad A, Jan BL, Raish M, et al. Evaluation of the in vivo genotoxicity of liposomal formulation for delivering anticancer estrogenic derivative (ESC8) in a mouse model. Saudi Pharmaceutical Journal. 2019; 27: 637-642.
10. Rina T, Pankaj T, Pancholi SS. Genotoxicity Studies of Diclofenac Sodium in the Bone Marrow and Germ cells of Laboratory Mice. Austin J Pharmacol Ther. 2014; 2(10): 8.
11. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Cyclophosphamide. In: Pharmaceuticals. IARC Monogr Eval Carcinog Risks Hum. 2012; 100(Pt A):63-90.