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Published: 2023-12-31
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DOI: https://doi.org/10.52852/tcncyh.v173i12E13.1898
Issue
Vol. 173 No. 12E13 (2023)
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Các bài báo
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Anh, P. T. V., Duong, D. T., Thang, N. H., Lien, N. T. H., Van, N. T. H., & Thanh, M. P. (2023). 6. Genotoxic evaluation of kovir capsules using mammalian bone marrow chromosomal aberration test. Journal of Medical Research, 173(12E13), 47-53. https://doi.org/10.52852/tcncyh.v173i12E13.1898

6. Genotoxic evaluation of kovir capsules using mammalian bone marrow chromosomal aberration test

Pham Thi Van Anh, Dau Thuy Duong, Nguyen Huu Thang, Nguyen Thi Huong Lien, Nguyen Thi Hong Van, Mai Phuong Thanh

Main Article Content

Abstract

The genotoxic potential of KOVIR capsules was investigated in vivo using the mammalian bone marrow chromosomal aberration test. Four groups of mice, seven in each group, were used in the study: Group I served as vehicle control; Group II received the positive control (cyclophosphamide 50 mg/kg; single dose; intraperitoneal route); and Group III to IV were given orally the KOVIR capsules, suspended in distilled water, at a single test dose of 2.16 and 4.32 capsules/kg, respectively. The obtained data disclosed the safety of KOVIR capsules, which did not show substantial genotoxic effects at either dose when compared with the vehicle group.

Article Details

Keywords

KOVIR, bone marrow, chromosome aberration, mice

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