Etiology and antimicrobial susceptibility of neonatal sepsis in the Neonatal Intensive Care Unit in Can Tho Children’s Hospital

Nguyen Ngoc Rang, Nguyen Vi Thu Ngoc

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Tóm tắt

This study aimed to determine the causative organisms in neonatal sepsis and their antimicrobial resistance patterns in the Neonatal Intensive Care Unit (NICU) of Can Tho Children’s Hospital in Vietnam. A retrospective descriptive study of neonatal sepsis was conducted from January 2018 to December 2019. A total of 139 neonates with positive blood culture was analyzed. Gram - positive bacteria (n = 84, 60.4%) were more common than Gram - negative bacteria (n = 49, 35.3%) and fungi (n = 6, 4.3%). Coagulase - negative Staphylococci (CONS) (28.3%) and Klebsiella pneumoniae (13.2%) were the most common cause of Early - onset sepsis, while CONS (39.5%) and Staphylococcus aureus (22.1%) were predominant isolates of Late - onset sepsis. Almost CONS and S. aureus were resistant to ampicillin and oxacillin, but susceptible to vancomycin (92 - 94%) and lizenolid (100%). K. pneumonia was resistant to cefotaxime (67%) and gentamicin (30%), but susceptible to imipenem (92%). Conclusion: CONS, S. aureus and K. pneumoniae were the most frequent pathogens in neonatal sepsis in our settings. Almost these strains were resistant to commonly used antibiotics. Change of first - line drugs should be based on the identification of isolated organisms and appropriate implementation of likely susceptible antibiotics would have a substantial impact on the outcomes.

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Tài liệu tham khảo

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