16. Risk of refeeding syndrome and related factors in esophageal cancer considering radiotherapy treatment

Tran Trung Bach, Nguyen Minh Nhat, Nguyen Thi Thanh, Nguyen Quang Duy, Vu Xuan Huy, Vo Van Xuan

Main Article Content

Abstract

A cross-sectional descriptive study was performed on 132 esophageal cancer patients at Tan Trieu General Radiotherapy Department of Vietnam National Cancer Hospital from March 2022 to March 2024 to evaluate the risk of developing refeeding syndrome at the time of considering radiation therapy indication. Median age at diagnosis was 60.7, male:female ratio was 131:1, 100% patients were diagnosed with squamous cell carcinoma. The majority of patients had upper third esophageal tumors (74.3%) and in locally advanced or metastatic stage (stage III-IV, 87.1%). The high risk rate of developing refeeding syndrome according to the standards of the UK National Institute for Healthcare Excellence (NICE) in 2017 was 29.5%. The length of the primary tumor (cut-off threshold was 6.7cm), grade 2 or more, dysphagia, weight loss at admission and enteral tube feeding through percutaneous gastrostomy were factors associated with high risk of developing refeeding syndrome (p < 0.05).

Article Details

References

1. Da Silva JSV, Seres DS, Sabino K, et al. ASPEN Consensus Recommendations for Refeeding Syndrome. Nut in Clin Prac. 2020;35(2):178-195. doi:10.1002/ncp.10474
2. Rasmussen SO, Kristensen MB, Wessel I, et al. Incidence and Risk Factors of Refeeding Syndrome in Head and Neck Cancer Patients-An Observational Study. Nutrition and Cancer. 2016;68(8):1320-1329. doi:10.1080/01635581.2016.1225103
3. González Avila G, Fajardo Rodríguez A, González Figueroa E. The incidence of the refeeding syndrome in cancer patients who receive artificial nutritional treatment. Nutr Hosp. 1996;11(2):98-101.
4. Szeja N, Grosicki S. Refeeding syndrome in hematological cancer patients - current approach. Expert Rev Hematol. 2020;13(3):201-212. doi:10.1080/17474086.2020.1727738
5. National Collaborating Centre for Acute Care (UK). Nutrition Support for Adults: Oral Nutrition Support, Enteral Tube Feeding and Parenteral Nutrition. National Institute for Health and Care Excellence (NICE); 2017. http://www.ncbi.nlm.nih.gov/books/NBK553310/
6. Kapała A. Nutrition treatment does not improve the efficacy of oncological treatment. Nowotwory Journal of Oncology. 2018;67(5):308-312. doi:10.5603/NJO.2017.0051
7. Kagansky N, Levy S, Koren-Morag N, et al. Hypophosphatemia in old patients is associated with the refeeding syndrome and reduced survival. J Intern Med. 2005;257:461-8.
8. Findlay M, Purvis M, Venman R, et al. Nutritional management of patients with oesophageal cancer throughout the treatment trajectory: benchmarking against best practice. Support Care Cancer. 2020;28(12):5963-5971. doi:10.1007/s00520-020-05416-x
9. Xu H, Wu S, Luo H, et al. Prognostic value of tumor length and diameter for esophageal squamous cell cancer patients treated with definitive (chemo)radiotherapy: Potential indicators for nonsurgical T staging. Cancer Med. 2019;8(14):6326-6334. doi:10.1002/cam 4.2532