Chế độ ăn sinh Ceton trong điều trị động kinh kháng trị tại Bệnh viện Nhi đồng 2

Abstract

More than 50 million people worldwide suffered from epilepsy, however, approximately 30% are drug resistant. The ketogenic diet (KD) has been firmly shown to be effective on some epilepsy syndromes, especially drug-resistant epilepsy syndromes in children. KD is still a new and challenged treatment in Vietnam. This is a descriptive prospective study of 31 pediatric patients with drug-resistant epilepsy, treated with a ketogenic diet at Children's Hospital 2, Ho Chi Minh City from September, 2019 to July, 2020. The menu was established by available Vietnamese foods. The patients were supplemented with vitamins, minerals and corrected the side effects. The feasibility was 93.5% (29/31). Tolerance rates were 75.86% (1 month), 65.52% (2 months) and 62.07% (3 months). 37.9% of patients had decreased seizures by 50% after 3 months of ketogenic diet.  The incidence of adverse events was 44.8%, with mild severity, and no patient discontinued the ketogenic diet. The rate of children suffering from acute malnutrition is 13.8% (initial) and 0% (after 3 months).