Nhận xét kết quả lâm sàng và chức năng thông khí sau điều trị bệnh phổi tắc nghẽn mạn tính bằng tế bào gốc tự thân từ mô mỡ
Nội dung chính của bài viết
Tóm tắt
Nghiên cứu đánh giá kết quảlâm sàng và chức năng thông khí sau điều trị bệnh phổi tắc nghẽn mạn tính bằng tế bào gốc tự thân từ mô mỡ. Nghiên cứu can thiệp thử nghiệm lâm sàng ở 20 bệnh nhân bệnh phổi tắc nghẽn mãn tính trên 40 tuổi với FEV1 < 60% vàcó ít nhất 2đợt cấp hoặc 1đợt cấp nhập viện trởlên trong 12 tháng trước được điều trị bằng tếbào gốc tự thân từ mô mỡ từ 1/2018 đến 8/2020, Trong nghiên cứu 100% nam giới với tuổi trung bình 66,25 ± 6,65. 100% bệnh nhân thuộc GOLD D. Nghiên cứu cho thấy sựcải thiện cóý nghĩa về điểm CAT, mMRC, SGRQ, BDI, chỉ sốBODE, khoảng cách đi bộ 6 phút tại thời điểm 3 tháng, 6 tháng sau truyền TBG tựthân từmô mỡlần 1 và lần 2 so với trước điều trị(P < 0,05). Chỉ sốFVC, FEV1 tăng so với trước điều trị. Trung bình FEV1 (%) tăng từ41,35 ± 12,283 (trước điều trị) lên 47,2 ± 10,63 (ở 6 tháng sau truyền TBG lần 2) (p > 0,05).
Chi tiết bài viết
Từ khóa
Bệnh phổi tắc nghẽn mạn tính, tế bào gốc mô mỡ
Tài liệu tham khảo
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26. Stolk J BW, Mauad T, Zwaginga J, Roelofs H, Fibbe W, Oostendorp J, Bajema I, Versteegh M, Taube C. A phase I study for intravenous auto logous mesenchymal stromal cell administration to patients with severe emphysema. QJM. 2016;109 (5):331 - 336.
27. Phuong Le Thi Bich HNT, Hoang Dang Ngo Chau, Tien Phan Van, Quyet Do, Hung Dong Khac, Dong Le Van, Luc Nguyen Huy, Khan Mai Cong, Thang Ta Ba, Trung Do Minh, Ngoc Vu Bich, Nhat Truong Chau and Phuc Van Pham. Al logeneic umbilical cord - derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study. Stem Cell Research & Therapy. 2020;11:60,
2. Mathers CD LD. Projections of global mortality and burden of disease from 2002 to 2030, PLoS Med. 2006;3 (11):e442.
3. Regional CWG. COPD prevalence in 12 Asia - Pacific countries and regions: projections based on the COPD prevalence estimation model. Respiro logy. 2003;8 2::192 - 198.
4. Galli V, Vaccarezza. Bone marrow - derived mesenchymal cell differentiation toward myogenic lineages: facts and perspectives. Biomed Res Int. 2014:762695.
5. Fan L et al. Directed differentiation of aged human bone marrow multipotent stem cells effectively generates dopamine neurons. In Vitro Cell Dev Biol Anim. 2014;50 4:304 - 312.
6. Gabr et al. Generation of insulin - producing cells from human bone marrow - derived mesenchymal stem cells: comparison of three differentiation protocols. Biomed Res Int. 2014:832736.
7. He H et al. Promotion of hepatic differentiation of bone marrow mesenchymal stem cells on decellularized cell - deposited extracellular matrix. Biomed Res Int. 2013:406871.
8. Kobayashi K et al. A tissue - engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose - derived stem cells. Biomaterials. 2010;31 18:4855 - 4863.
9. Yin L et al. Adipose tissue - derived mesenchymal stem cells differentiated into hepatocyte - like cells in vivo and in vitro. Mol Med Rep. 2015;113:1722 - 1732.
10, PDı´az - Agero A lvarez MGa - A, T Georgiev - Hristov, D Garcı´a - Olmo. A new bronchoscopic treatment of tracheomediastinal fistula using auto logous adiposederived stem cells. Thorax. 2008;63:374 - 376.
11. Argyris Tzouvelekis VP, George Koliakos, Paschalis Ntolios. A prospective, non - randomized, no placebo - controlled, phase Ib clinical trialto study the safety of the adipose derived stromal cells - stromal vascular fraction in idiopathic pulmonary fibrosis. Journal of Translational Medicine. 2013;11:171.
12. Guoping Zheng LH, Haijiang Tong, Qiang Shu, Yaoqin Hu, Menghua Ge, Liuya Zhang, Bin Zou, Baoli Cheng, Jianguo Xu. Treatment of acute respiratory distress syndrome with al logeneic adipose - derived mesenchymal stem cells: a randomized, placebo - controlled pilot study. Respiratory Research. 2014;15:39.
13. Kristin Comella JAPB, Tom Ichim, Javier Lopez, Jose Limon, Ruben Corral Moreno. Auto logous Stromal Vascular Fraction in the Intravenous Treatment of End - Stage Chronic Obstructive Pulmonary Disease: A Phase I Trial of Safety and Tolerability. J Clin Med Res. 2017;9 (8):701 - 708.
14. GOLD. Global strategy for diagnosis, management and prevention of COPD. NHLBI/WHO workshop report. 2016.
15. Jones PW QF, Baveystock CM. The St George’s Respiratory Questionnaire. Respir Med. 1991;85:25 - 31.
16. Jones PW HG, Berry P, Wiklund I, Chen WH, Kline Leidy N,. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009;34 (3):648 - 654.
17. Celli BR CC, Marin JM, et al. The body - mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350 (10):1005 - 1012.
18. Laurendeau C PC, Perez T, Roche N, Simeoni MC, Detournay B. [Validation study of the BDI/TDI scores in chronic obstructive pulmonary disease]. Rev Mal Respir. 2009;26 (7):735 - 743.
19. Laboratories ACoPSfCPF. ATS statement: guidelines for six - minute walk test. Am J Respir Crit Care Med. 2002;166:111 - 117.
20, Duncan B Ross MP. Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease. 2014. https://clinicaltrials. gov/ct2/show/NCT02216630,
21. McQuillan S. Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease. https://clinicaltrials. gov/ct2/show/NCT01559051.
22. Fischer - Laycock Y. Safety Tolerability and Preliminary Efficacy of Adipose Derived Stem Cells for Patients With Chronic Obstructive Pulmonary Disease. 2015.. https://clinicaltrials. gov/ct2/show/NCT02161744.
23. Weiss DJ CR, Flannery R, LeRoux - Williams M, Tashkin DP. A placebocontrolled, randomized trial of mesenchymal stem cells in COPD. Chest. 2013;143 (6):1590 - 1598.
24. Ribeiro - Paes JT, Aldemir Bilaqui, Oswaldo T Greco et al. Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema. International journal of chronic obstructive pulmonary disease. 2011:63 - 71.
25. Stessuk T RM, Greco OT, Bilaqui A, MJdO R - P, Ribeiro - Paes JT. Phase I clinical trial of cell therapy in patients with advanced chronic obstructive pulmonary disease: follow - up of up to 3 years. Rev Bras Hematol Hemoter. 2013;35 (5):352 - 357.
26. Stolk J BW, Mauad T, Zwaginga J, Roelofs H, Fibbe W, Oostendorp J, Bajema I, Versteegh M, Taube C. A phase I study for intravenous auto logous mesenchymal stromal cell administration to patients with severe emphysema. QJM. 2016;109 (5):331 - 336.
27. Phuong Le Thi Bich HNT, Hoang Dang Ngo Chau, Tien Phan Van, Quyet Do, Hung Dong Khac, Dong Le Van, Luc Nguyen Huy, Khan Mai Cong, Thang Ta Ba, Trung Do Minh, Ngoc Vu Bich, Nhat Truong Chau and Phuc Van Pham. Al logeneic umbilical cord - derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study. Stem Cell Research & Therapy. 2020;11:60,