Clinical outcome and ventilatory function after treatment of copd with autologous adipose-derived stem cells
Main Article Content
Abstract
This clinical triall study was conducted to assess the clinical outcome and ventilatory function after treatment of COPD with autologous adipose - derived stem cells. 20 male patients over 40 years old, diagnosed for COPD with a FEV1 <60% and at least two exacerbations or one or more hospitalizations due to exacerbation within 12 months were assessed from January 2018 to August 2020, Result showed that mean age 66.25 ± 6.648. Average duration of ailment was6.37 ± 2.867 (years), 100% of GOLD D patients. There is significant improvement in CAT, mMRC, SGRQ, BDI, BODE index, 6 - minutes walking test at 3 months, 6 months after the first and second autologous adipose - derived stem cells infusion than baseline (p < 0,05). FVC improved compare to baseline, Mean FEV1 (%) increased from 41.35 ± 12.283 (at baseline) to 47.2 ± 10,633 (at 6 months after the 2nd autologous adipose - derived stem cells infusion) (p > 0,05). Treatment of COPD with autologous adipose - derived stem cells improved clinical outcome including dyspnea, exercise capacity and quality of life, while no signification improvement of ventilation function.
Article Details
Keywords
COPD, adipose - derived stem cells
References
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2. Mathers CD LD. Projections of global mortality and burden of disease from 2002 to 2030, PLoS Med. 2006;3 (11):e442.
3. Regional CWG. COPD prevalence in 12 Asia - Pacific countries and regions: projections based on the COPD prevalence estimation model. Respiro logy. 2003;8 2::192 - 198.
4. Galli V, Vaccarezza. Bone marrow - derived mesenchymal cell differentiation toward myogenic lineages: facts and perspectives. Biomed Res Int. 2014:762695.
5. Fan L et al. Directed differentiation of aged human bone marrow multipotent stem cells effectively generates dopamine neurons. In Vitro Cell Dev Biol Anim. 2014;50 4:304 - 312.
6. Gabr et al. Generation of insulin - producing cells from human bone marrow - derived mesenchymal stem cells: comparison of three differentiation protocols. Biomed Res Int. 2014:832736.
7. He H et al. Promotion of hepatic differentiation of bone marrow mesenchymal stem cells on decellularized cell - deposited extracellular matrix. Biomed Res Int. 2013:406871.
8. Kobayashi K et al. A tissue - engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose - derived stem cells. Biomaterials. 2010;31 18:4855 - 4863.
9. Yin L et al. Adipose tissue - derived mesenchymal stem cells differentiated into hepatocyte - like cells in vivo and in vitro. Mol Med Rep. 2015;113:1722 - 1732.
10, PDı´az - Agero A lvarez MGa - A, T Georgiev - Hristov, D Garcı´a - Olmo. A new bronchoscopic treatment of tracheomediastinal fistula using auto logous adiposederived stem cells. Thorax. 2008;63:374 - 376.
11. Argyris Tzouvelekis VP, George Koliakos, Paschalis Ntolios. A prospective, non - randomized, no placebo - controlled, phase Ib clinical trialto study the safety of the adipose derived stromal cells - stromal vascular fraction in idiopathic pulmonary fibrosis. Journal of Translational Medicine. 2013;11:171.
12. Guoping Zheng LH, Haijiang Tong, Qiang Shu, Yaoqin Hu, Menghua Ge, Liuya Zhang, Bin Zou, Baoli Cheng, Jianguo Xu. Treatment of acute respiratory distress syndrome with al logeneic adipose - derived mesenchymal stem cells: a randomized, placebo - controlled pilot study. Respiratory Research. 2014;15:39.
13. Kristin Comella JAPB, Tom Ichim, Javier Lopez, Jose Limon, Ruben Corral Moreno. Auto logous Stromal Vascular Fraction in the Intravenous Treatment of End - Stage Chronic Obstructive Pulmonary Disease: A Phase I Trial of Safety and Tolerability. J Clin Med Res. 2017;9 (8):701 - 708.
14. GOLD. Global strategy for diagnosis, management and prevention of COPD. NHLBI/WHO workshop report. 2016.
15. Jones PW QF, Baveystock CM. The St George’s Respiratory Questionnaire. Respir Med. 1991;85:25 - 31.
16. Jones PW HG, Berry P, Wiklund I, Chen WH, Kline Leidy N,. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009;34 (3):648 - 654.
17. Celli BR CC, Marin JM, et al. The body - mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350 (10):1005 - 1012.
18. Laurendeau C PC, Perez T, Roche N, Simeoni MC, Detournay B. [Validation study of the BDI/TDI scores in chronic obstructive pulmonary disease]. Rev Mal Respir. 2009;26 (7):735 - 743.
19. Laboratories ACoPSfCPF. ATS statement: guidelines for six - minute walk test. Am J Respir Crit Care Med. 2002;166:111 - 117.
20, Duncan B Ross MP. Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease. 2014. https://clinicaltrials. gov/ct2/show/NCT02216630,
21. McQuillan S. Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease. https://clinicaltrials. gov/ct2/show/NCT01559051.
22. Fischer - Laycock Y. Safety Tolerability and Preliminary Efficacy of Adipose Derived Stem Cells for Patients With Chronic Obstructive Pulmonary Disease. 2015.. https://clinicaltrials. gov/ct2/show/NCT02161744.
23. Weiss DJ CR, Flannery R, LeRoux - Williams M, Tashkin DP. A placebocontrolled, randomized trial of mesenchymal stem cells in COPD. Chest. 2013;143 (6):1590 - 1598.
24. Ribeiro - Paes JT, Aldemir Bilaqui, Oswaldo T Greco et al. Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema. International journal of chronic obstructive pulmonary disease. 2011:63 - 71.
25. Stessuk T RM, Greco OT, Bilaqui A, MJdO R - P, Ribeiro - Paes JT. Phase I clinical trial of cell therapy in patients with advanced chronic obstructive pulmonary disease: follow - up of up to 3 years. Rev Bras Hematol Hemoter. 2013;35 (5):352 - 357.
26. Stolk J BW, Mauad T, Zwaginga J, Roelofs H, Fibbe W, Oostendorp J, Bajema I, Versteegh M, Taube C. A phase I study for intravenous auto logous mesenchymal stromal cell administration to patients with severe emphysema. QJM. 2016;109 (5):331 - 336.
27. Phuong Le Thi Bich HNT, Hoang Dang Ngo Chau, Tien Phan Van, Quyet Do, Hung Dong Khac, Dong Le Van, Luc Nguyen Huy, Khan Mai Cong, Thang Ta Ba, Trung Do Minh, Ngoc Vu Bich, Nhat Truong Chau and Phuc Van Pham. Al logeneic umbilical cord - derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study. Stem Cell Research & Therapy. 2020;11:60,