Motor functional recovery after rehabilitation following parasagittal meningioma surgery: A prospective interventional study from Vietnam

Nguyen Thi Thu Thuy, Ha Thi Huong Giang, Nguyen Thi Kim Lien

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Tóm tắt

This prospective single-group interventional study aimed to evaluate motor functional recovery and identify factors associated with rehabilitation outcomes in patients following parasagittal meningioma surgery. Thirty patients presenting with postoperative motor weakness after tumor resection participated in a standardized 2-week inpatient rehabilitation program combining physical and occupational therapy, followed by outpatient continuation. Motor and functional outcomes were assessed using the Motor Assessment Scale (MAS), Manual Muscle Testing (MMT), and Functional Independence Measure (FIM) at baseline, 1 month, and 3 months post-intervention. Significant improvements were observed across all scales, with MAS increasing from 30.1 ± 10.9 to 37.8 ± 8.5 and 39.2 ± 8.4, MMT from 126.3 ± 19.8 to 136.0 ± 20.2 and 141.6 ± 18.8, and FIM from 85.0 ± 29.6 to 93.4 ± 20.3 and 99.7 ± 18.6 (p < 0.05 for all comparisons). Generalized Estimating Equations analysis revealed that age, peritumoral edema and preoperative motor weakness were not significant predictors. These findings support the role of early, targeted rehabilitation as a beneficial component of postoperative care for patients with parasagittal meningioma. Larger controlled studies with longer follow-up are required to better delineate recovery trajectories and clarify factors influencing rehabilitation outcomes in this population.

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Tài liệu tham khảo

1. Baldi I, Engelhardt J, Bonnet C, et al. Epidemiology of meningiomas. Neurochirurgie. 2018; 64(1): 5-14.
2. Mathiesen T. Parasagittal meningiomas. Handb Clin Neurol. 2020; 170: 93-100.
3. Alruwaili AA, De Jesus O. Meningioma. In: StatPearls. StatPearls Publishing; 2023.
4. Caruso G, Ferrarotto R, Curcio A, et al. Novel Advances in Treatment of Meningiomas: Prognostic and Therapeutic Implications. Cancers. 2023; 15(18): 4521.
5. Zweckberger K, Hallek E, Vogt L, Giese H, Schick U, Unterberg AW. Prospective analysis of neuropsychological deficits following resection of benign skull base meningiomas. J Neurosurg. 2017; 127(6): 1242-1248.
6. Ekaireb RI, Edwards CS, Ali MS, et al. Meningioma surgical outcomes and complications in patients aged 75 years and older. J Clin Neurosci Off J Neurosurg Soc Australas. 2021; 88: 88-94.
7. Magill ST, Nguyen MP, Aghi MK, Theodosopoulos PV, Villanueva-Meyer JE, McDermott MW. Postoperative diffusion-weighted imaging and neurological outcome after convexity meningioma resection. J Neurosurg. 2021; 135(4): 1008-1015.
8. Nguyen MP, Morshed RA, Cheung SW, Theodosopoulos PV, McDermott MW. Postoperative Complications and Neurological Deficits After Petroclival Region Meningioma Resection: A Case Series. Oper Neurosurg Hagerstown Md. 2023; 25(3): 251-259.
9. Huang ME, Wartella JE, Kreutzer JS. Functional outcomes and quality of life in patients with brain tumors: a preliminary report. Arch Phys Med Rehabil. 2001; 82(11): 1540-1546.
10. Greenberg E, Treger I, Ring H. Rehabilitation outcomes in patients with brain tumors and acute stroke: comparative study of inpatient rehabilitation. Am J Phys Med Rehabil. 2006;85(7):568-573.
11. Geler-Kulcu D, Gulsen G, Buyukbaba E, Ozkan D. Functional recovery of patients with brain tumor or acute stroke after rehabilitation: a comparative study. J Clin Neurosci Off J Neurosurg Soc Australas. 2009; 16(1): 74-78.
12. Fu JB, Parsons HA, Shin KY, et al. Comparison of functional outcomes in low- and high-grade astrocytoma rehabilitation inpatients. Am J Phys Med Rehabil. 2010; 89(3): 205-212.
13. Bartolo M, Zucchella C, Pace A, et al. Early rehabilitation after surgery improves functional outcome in inpatients with brain tumours. J Neurooncol. 2012; 107(3): 537-544.
14. Thakkar P, Greenwald B, Patel P. Rehabilitation of Adult Patients with Primary Brain Tumors: A Narrative Review. Brain Sci. 2020; 10(8): 492.
15. Goldsworthy MR, Rogasch NC, Ballinger S, et al. Age-related decline of neuroplasticity to intermittent theta burst stimulation of the lateral prefrontal cortex and its relationship with late-life memory performance. Clin Neurophysiol. 2020; 131(9): 2181-2191.
16. Ahmeti H, Caliebe A, Röcken C, Jansen O, Mehdorn MH, Synowitz M. Impact of peritumoral brain edema on pre- and postoperative clinical conditions and on long-term outcomes in patients with intracranial meningiomas. Eur J Med Res. 2023; 28(1): 40.
17. Krajewski S, Furtak J, Zawadka-Kunikowska M, Kachelski M, Birski M, Harat M. Rehabilitation Outcomes for Patients with Motor Deficits after Initial and Repeat Brain Tumor Surgery. Int J Environ Res Public Health. 2022; 19(17): 10871.