Article Sidebar

PDF (Tiếng Việt)
Published: 2021-05-25
Abstract Views: 832
Views PDF (Tiếng Việt): 667
DOI: https://doi.org/10.52852/tcncyh.v139i3.101
Issue
Vol. 139 No. 3 (2021)
Section
Các bài báo
How to Cite
Khải, T. Q. ., Thúy, N. T. D., Hùng, T. Đỗ ., & Vân, P. H. . (2021). Co - infections in children with severe community-acquired pneumonia. Journal of Medical Research, 139(3), 45-54. https://doi.org/10.52852/tcncyh.v139i3.101

Co - infections in children with severe community-acquired pneumonia

Trần Quang Khải, Nguyễn Thị Diệu Thúy, Trần Đỗ Hùng, Phạm Hùng Vân

Main Article Content

Abstract

Pneumonia is one of the leading causes of death in children under 5 years old. Historically, viruses have been the most co mmon cause of co mmunity - acquired pneumonia in children. Co - infections in severe pneumonia are of concern by physicians. Real - time PCR is a modern test to detect many pathogens, including co - infections. Therefore, we applied this technique to investigate the causes of severe pneumonia. Through the analysis of 95 samples, there were 90.5% of PCR positive. Virus - bacteria co - infection accounted in highest proportion (43.1%), followed by bacterial - bacterial co - infection (33.7%), virus infection was 7.4% and bacterial causes was 6.3% with 9.5% causes was unknown. In the co - infection group, the following five bacterial species were co mmonly involved, in descending order including Streptococcus pneumoniae, Haemophilus influenzae, MRSA, Moraxella catarrhalis and Mycoplasma pneumoniae. As a result, antibiotic treatment should focus on these microbes in cases of severe pneumonia.

Article Details

Keywords

co - infection, bacteria, co mmunity - acquired pneumonia, children.

References

1. McAllister DA, Liu L, Shi T, et al. Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis. The Lancet Global health. 2019;7 (1):e47 - e57.
2. Marcelo CS, Paulo JCM, Renato TS. Pneumonia in children. In: Wilmott RW, ed. Kendig’s Disorders of the Respiratory Tract in Children. 9th ed. Philadelphia: PA: Elsevier; 2018:1597 - 1644.
3. Principi N, Esposito S. Biomarkers in Pediatric Co mmunity - Acquired Pneumonia. International journal of molecular sciences. 2017;18 (2):447. doi: 410. 3390/ijms18020447.
4. Okomo U, Idoko OT, Kampmann B. The burden of viral respiratory infections in young children in low - resource settings. The Lancet Global health. 2020;8 (4):e454 - e455.
5. Charlton CL, Babady E, Ginocchio CC, et al. Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections. Clinical microbiology reviews. 2019;32 (1):e42 - e90.
6. Nolan VG, Arnold SR, Bramley AM, et al. Etiology and Impact of Coinfections in Children Hospitalized With Co mmunity - Acquired Pneumonia. The Journal of infectious diseases. 2018;218 (2):179 - 188.
7. Bộ Y Tế. Quyết định số 101/QĐ - BYT ban hành Hướng dẫn xử trí viêm phổi cộng đồng ở trẻ em. In. Hà Nội. 2014:1 - 15.
8. Bowen SJ, Thomson AH. British Thoracic Society Paediatric Pneumonia Audit: a review of 3 years of data. Thorax. 2013;68 (7):682 - 683.
9. Nguyễn Phước Hưng. Khảo sát nồng độ procalcitonin máu ở trẻ từ 2 tháng đến 15 tuổi bị viêm phổi tại bệnh viện Đa khoa Đồng Tháp. Tạp chí Y học Thành phố Hồ Chí Minh. 2016;20 (1):31 - 36.
10. Williams DJ, Zhu Y, Grijalva CG, et al. Predicting Severe Pneumonia Outcomes in Children. Pediatrics. 2016;138 (4):e20161019. doi: 20161010. 20161542/peds. 20162016 - 20161019.
11. Jain S, Williams DJ, Arnold SR, et al. Co mmunity - acquired pneumonia requiring hospitalization among U. S. children. The New England journal of medicine. 2015;372 (9):835 - 845.
12. Rees CA, Basnet S, Gentile A, et al. An analysis of clinical predictive values for radiographic pneumonia in children. BMJ global health. 2020;5 (8):e2708. doi: 2710. 1136/bmjgh - 2020 - 002708.
13. Shah SN, Bachur RG, Simel DL, Neuman MI. Does This Child Have Pneumonia?: The Rational Clinical Examination Systematic Review. Jama. 2017;318 (5):462 - 471.
14. Esposito S, Bianchini S, Gambino M, et al. Measurement of lipocalin - 2 and syndecan - 4 levels to differentiate bacterial from viral infection in children with co mmunity - acquired pneumonia. BMC pulmonary medicine. 2016;16 (1):103.
15. le Roux DM, Zar HJ. Co mmunity - acquired pneumonia in children - a changing spectrum of disease. Pediatric radiology. 2017;47 (11):1392 - 1398.
16. Nathan AM, Teh CSJ, Jabar KA, et al. Bacterial pneumonia and its associated factors in children from a developing country: A prospective cohort study. PloS one. 2020;15 (2):e0228056. doi: 0228010. 0221371/journal. pone. 0228056.
17. Bénet T, Sánchez Picot V, Messaoudi M, et al. Microorganisms Associated With Pneumonia in Children < 5 Years of Age in Developing and Emerging Countries: The GABRIEL Pneumonia Multicenter, Prospective, Case - Control Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2017;65 (4):604 - 612.
18. Meyer Sauteur PM, Krautter S, Ambroggio L, et al. Improved diagnostics help to identify clinical features and biomarkers that predict Mycoplasma pneumoniae co mmunity - acquired pneumonia in children. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2019:ciz1059. doi: 1010. 1093/cid/ciz1059.
19. Chen YC, Hsu WY, Chang TH. Macrolide - Resistant Mycoplasma pneumoniae Infections in Pediatric Co mmunity - Acquired Pneumonia. Emerging infectious diseases. 2020;26 (7):1382 - 1391.