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Published: 2022-09-15
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DOI: https://doi.org/10.52852/tcncyh.v157i9.1041
Issue
Vol. 157 No. 9 (2022)
Section
Các bài báo
How to Cite
Long, N. T. ., Khánh, T. V. ., Tú, H. C. ., Thu, V. T. H. ., Văn, T. T. ., & Thúy, N. T. . (2022). 2. Single nucleotide polymorphism rs3077 of HLA-DP gene in Hepatitis B virus-infected liver cirrhosis patients . Journal of Medical Research, 157(9), 9-16. https://doi.org/10.52852/tcncyh.v157i9.1041

2. Single nucleotide polymorphism rs3077 of HLA-DP gene in Hepatitis B virus-infected liver cirrhosis patients

Nguyen Tien Long, Tran Van Khanh, Ho Cam Tu, Vu Thi Hoai Thu, Ta Thanh Van, Nguyen Thu Thuy

Main Article Content

Abstract

The human leukocyte antigen (HLA) gene system encodes cell surface receptor proteins which is responsible for the regulation of the immune system. The single nucleotide polymorphism (SNP) rs3077 of HLA-DP gene is thought to have a role in Hepatitis B virus (HBV) infection and against late-stage of liver fibrosis. This study aims to determine the distribution of SNP rs3077 in HBV-infected cirrhotic patients and the relation between SNP rs3077 and the risk of liver cirrhosis. Realtime-PCR technique was used to genotype SNP rs3077 in HBV-infected cirrhosis and chronic Hepatitis B patients. The results showed that the proportion of AA, AG, GG genotypes of cirrhosis and chronic Hepatitis B groups were 5.1%, 39.7%, 55,1% and 11.2%, 38.8%, 50.0%, respectively. Frequency of alleles and genotypes of rs3077 of the two groups was not significant different. In conclusion, the relation between SNP rs3077 and the risk of liver cirrhosis from chronic HBV infection has not been found.

Article Details

Keywords

Cirrhosis, SNP rs3077, HLA-DP gene, HBV

References

1. Đào Văn Long. Xơ gan. Bệnh học Nội khoa. Trường Đại học Y Hà Nội.
2. Vos T, Lim SS, Abbafati C, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990 - 2019: A systematic analysis for the global burden of disease study 2019. The Lancet. 2020;396(10258):1204-1222. doi: 10.1016/S01 40-6736(20)30925-9.
3. Pimpin L, Cortez-Pinto H, Negro F, et al. Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies. J Hepatol. 2018;69(3):718-735. doi: 10.1016/j.jhep.2018.05.011.
4. Al-Qahtani AA, Al-Anazi MR, Abdo AA, et al. Association between HLA variations and chronic Hepatitis B virus infection in Saudi Arabian patients. PloS One. 2014;9(1):e80445. doi: 10.1371/journal.pone.0080445.
5. Zeng Z, Liu H, Xu H, et al. Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression. BMC Med Genomics. 2021;14(1):84. doi: 10.1186/s12920-021-0090 7-0.
6. Akcay IM, Katrinli S, Ozdil K, Doganay GD, Doganay L. Host genetic factors affecting Hepatitis B infection outcomes: Insights from genome-wide association studies. World J Gastroenterol. 2018;24(30):3347-3360. doi: 10. 3748/wjg.v24.i30.3347.
7. Hirayama K, Chen H, Kikuchi M, et al. HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population. Tissue Antigens. 1999;53(3):269-274. doi: 10.1034/j.1 399-0039.1999.530307.x.
8. Zhang Q, Yin J, Zhang Y, et al. HLA-DP polymorphisms affect the outcomes of chronic Hepatitis B virus infections, possibly through interacting with viral mutations. J Virol. 2013;87(22):12176-12186. doi: 10.1128/JVI.02073-13.
9. Posuwan N, Payungporn S, Tangkijvanich P, et al. Genetic association of human leukocyte antigens with chronicity or resolution of Hepatitis B infection in Thai population. PloS One. 2014;9(1):e86007. doi: 10.1371/journal.pone.0086007.
10. Wong DKH, Watanabe T, Tanaka Y, et al. Role of HLA-DP polymorphisms on chronicity and disease activity of Hepatitis B infection in Southern Chinese. PloS One. 2013;8(6):e66920. doi: 10.1371/journal.pone. 0066920.
11. Nishida N, Sawai H, Matsuura K, et al. Genome-wide association study confirming association of HLA-DP with protection against chronic Hepatitis B and viral clearance in Japanese and Korean. PloS One. 2012;7(6):e39175. doi: 10.1371/journal.pone.0039175.
12. Li Y, Huang Q, Tang JT, et al. Correlation of HLA-DP/DQ polymorphisms with transplant etiologies and prognosis in liver transplant recipients. Medicine (Baltimore). 2017;96(25):e7205. doi: 10.1097/MD.000000000000720. https://www.who.int/ne ws-room/fact-sheets/detail/hepatitis-b.
13. Hu Z, Yang J, Xiong G, et al. HLA-DPB1 variant effect on Hepatitis B virus clearance and liver cirrhosis development among Southwest Chinese population. Hepat Mon. 2014;14(8):e19747. doi: 10.5812/hepatmon. 19747.
14. An P, Winkler C, Guan L, O'Brien SJ, Zeng Z, HBV Study Consortium. A common HLA-DPA1 variant is a major determinant of Hepatitis B virus clearance in Han Chinese. J Infect Dis. 2011;203(7):943-947. doi: 10.1093/infdis/jiq154.
15. Kamatani Y, Wattanapokayakit S, Ochi H, et al. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic Hepatitis B in Asians. Nat Genet. 2009;41(5):591-595. doi: 10.1038/ng.348.
16. Migita K, Abiru S, Ohtani M, et al. HLA-DP gene polymorphisms and Hepatitis B infection in the Japanese population. Transl Res J Lab Clin Med. 2012;160(6):443-444. doi: 10.1016/j.trsl.2012.06.003.
17. Guo X, Zhang Y, Li J, et al. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic Hepatitis B virus carriers in the Han Chinese population. Hepatol Baltim Md. 2011; 53(2):422-428. doi: 10.1002/hep.24048.
18. Katrinli S, Enc FY, Ozdil K, et al. Effect of HLA-DPA1 alleles on chronic Hepatitis B prognosis and treatment response. North Clin Istanb. 2016;3(3):168-174. doi: 10.14744/nci.2 016.27870.