Reference centile charts of f- βhCG, PAPP - Aandnuchal translucency in 11 - 13 week 06 day fetus
Main Article Content
Abstract
This study was conducted to assess the correlation between the crow-rump length (CRL) and nuchal translucency, PAPP-A, free β-hCG, and build their 5th, 50th, 95th value in normal fetus. A total of 2604 women with singleton pregnancies between 11 and 13 week and 6 days at the Center of Prenatal Diagnostic of National Hospital were enrolled in the study. CRL and nuchal translucency (NT) were measured, and test of PAPP-A and free β-hCG were conducted. The means, standards derivation, and correlation between CRL and NT, PAPP-A and free β-hCG were calculated; the equations for NT, PAPP-A and free β-hCG were derived. Results showed that the average CRL was 61.09 ± 7.16mm, average NT was 1.32 ± 0.36mm, average PAPP-A was 3833.78 ± 749.23 mU/l, average free β-hCG was 70.22 ± 48.15 ng/ml. The regression equation for NT was 0,342 + CRLx 0,015
(R2 = 0.076), for PAPP-A = 104.579x CRL- 2555.937 (R2 = 0.107), free β-hCG = 114.117- 0.718x CRL (R2 = 0.011). In conclusion, there is the correlation between CRL and NT, PAPP-A, free βhCG. The reference centile charts of first trimester aneuploidy screening were derived in Vietnamese pregnant women. These centile charts may be used as a reference for clinical use in Vietnam population.
Article Details
Keywords
crow-rump length (CRL), nuchal translucency (NT), PAPP-A, free β-hCG, percentile
References
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