12. Common adverse events following immunization with moderna Covid-19 vaccine among Vietnamese adults at Hanoi Medical University in 2021
Main Article Content
Abstract
The rapid creation of vaccinations has increased the risk of vaccine safety. In less than two years, a significant number of COVID-19 vaccines were developed and approved in various countries to control the COVID-19 pandemic. This study was conducted to identify the common adverse events following immunization with mRNA-1273 (Moderna COVID-19) vaccine among adults in 2021. A cross-sectional study using randomized sampling was conducted in Hanoi, Vietnam, with 766 participants. The results show that the prevalence of AEFIs after the 1st dose was significantly lower than after the 2nd dose (41.25% vs. 85.64%, p < 0.05). Local effects, fever, fatigue, and increased pain sensation were the most common side effects encountered in both 1st and 2nd dose. The AEFIs are mostly mild and automatically wore off after one to three days. Therefore, the Moderna COVID-19 vaccine is safe for injection.
Article Details
Keywords
Adverse events, immunization, Moderna COVID-19 vaccine, mRNA-1273, adult
References
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3. Suppawittaya P, Yiemphat P, Yasri P. Effects of Social Distancing, Self-Quarantine and Self-Isolation during the COVID-19 Pandemic on People’s Well-Being, and How to Cope with It. 2020:
4. Health NIo. COVID-19 Vaccine Development: Behind the Scenes. Accessed May 25th, 2022, https://covid19.nih.gov/news-and-stories/vaccine-development
5. Data OWi. Coronavirus (COVID-19) Vaccinations. Accessed May 17th, 2022, https://ourworldindata.org/covid-vaccinations.
6. WHO. Status of COVID-19 Vaccines within WHO EUL/PQ evaluation process. Accessed May 17th, 2022, https://extranet.who.int/pqweb/sites/default/files/documents/Status_COVID_VAX_18February2022.pdf.
7. Wikipedia. Silicon dioxide. Accessed 20/5/2019, https://en.wikipedia.org/wiki/Silicon_dioxide#Health_effects.
8. CDC. Moderna COVID-19 Vaccine (also known as Spikevax): Overview and Safety. Accessed March 1st, 2022, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/Moderna.html#:~:text=Moderna%20(Spikevax)%20COVID%2D19,the%20Moderna%20COVID%2D19%20vaccine.
9. FDA. Vaccine information fact sheet for recipients and caregivers about Spikevax (COVID-19 vaccine, mRNA) and the Moderna COVID-19 vaccine to prevent coronavirus disease 2019 (covid-19) in individuals 12 years of age and older. Accessed March 1st, 2022, https://www.fda.gov/media/144638/download
10. Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. Feb 4 2021; 384(5): 403-416. doi:10.1056/NEJMoa2035389.
11. Jeon M, Kim J, Oh CE, Lee JY. Adverse Events Following Immunization Associated with Coronavirus Disease 2019 Vaccination Reported in the Mobile Vaccine Adverse Events Reporting System. J Korean Med Sci. May 3 2021; 36(17): e114. doi:10.3346/jkms.2021.36.e114.
12. Kitagawa H, Kaiki Y, Sugiyama A, et al. Adverse reactions to the BNT162b2 and mRNA-1273 mRNA COVID-19 vaccines in Japan. J Infect Chemother. Apr 2022; 28(4): 576-581. doi:10.1016/j.jiac.2021.12.034.
13. Valera-Rubio M, Sierra-Torres MI, Castillejo García R, et al. Adverse events reported after administration of BNT162b2 and mRNA-1273 COVID-19 vaccines among hospital workers: a cross-sectional survey-based study in a Spanish hospital. Expert Review of Vaccines. 2022/04/03 2022; 21(4): 533-540. doi:10.1080/14760584.2022.2022478.
14. WHO. Ten threats to global health in 2019. Accessed May 20, 2022, https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-2019.
15. Tran VN, Nguyen HA, Le TTA, Truong TT, Nguyen PT, Nguyen TTH. Factors influencing adverse events following immunization with AZD1222 in Vietnamese adults during first half of 2021. Vaccine. Oct 22 2021; 39(44): 6485-6491. doi:10.1016/j.vaccine.2021.09.060.
16. Health VMo. Decision No. 5785 on the issuance of temporary guidelines for vaccine screening for COVID-19. 2021;
17. Parés-Badell O, Martínez-Gómez X, Pinós L, et al. Local and Systemic Adverse Reactions to mRNA COVID-19 Vaccines Comparing Two Vaccine Types and Occurrence of Previous COVID-19 Infection. Vaccines (Basel). Dec 10 2021; 9(12) doi: 10.3390/vaccines9121463.
18. Manuela A. Hoffmann, Helmut J. Wieler, Peter Enders, Hans-Georg Buchholz, Bodo Plachter. Age- and Sex-Graded Data Evaluation of Vaccination Reactions after Initial Injection of the BNT162b2 mRNA Vaccine in a Local Vaccination Center in Germany. Vaccines 2021; 9(8): 911.
19. Renuka A.K. Kadali, Ravali Janagama, Sharanya Peruru, Srikrishna V. Malayala. Side effects of BNT162b2 mRNA COVID-19 vaccine: A randomized, cross-sectional study with detailed self-reported symptoms from healthcare workers. International Journal of Infectious Diseases. 2021; 106(2021): 376-381.
20. Elterman K. Why Are Pfizer and Moderna Vaccines’ Side Effects Worse After the Second Shot? Accessed May 20, 2022, https://www.goodrx.com/conditions/covid-19/why-side-effects-worse-after-second-covid-19-shot.
21. Chapin-Bardales J, Gee J, Myers T. Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines. Jama. Jun 1 2021; 325(21): 2201-2202. doi:10.1001/jama.2021.5374.