26. Clinical utilization of prolonged low dose thrombolytic therapy for mechanical prosthetic valve thrombosis: Case reports from Hanoi Medical University Hospital
Main Article Content
Abstract
Thrombosis on a mechanical prosthetic valve is a life-threatening complication after valve replacement surgery, in most case due to non - adherence or ineffective anticoagulation. Beside surgery, prolonged low-dose thrombolytic therapy is a potentially safe, noninvasive, and effective therapy that can be done at the ED with counsel from experiencedpcardiologists. We present here two cases of thrombosis on mechanical valve that have been successfully treated by utilization of prolong low dose thrombolysis therapy.
Article Details
Keywords
prolonged low-dose thrombolytic therapy, mechanical prosthetic valve, thrombosis
References
2. European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). 2021 ESC/EACTS Guidelines for the management of valvular heart disease. 2022. https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/2021-Valvular-Heart-Disease. Published 28 Aug 2021. Accessed 20 Aug 2022.
3. American College of Cardiology/American Heart Association (ACC/AHA). 2017 AHA/ACC Focused Update of Valvular Heart Disease Guideline. https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000503. Published 15 Mar 2017. Accessed 20 Aug 2022.
4. Tong AT, Roudaut R, Ozkan M. Transesophageal echocardiography improves risk assessment of thrombolysis of prosthetic valve thrombosis: results of the international PRO-TEE registry. J Am Coll Cardiol. 2004 Jan 7;43(1):77-84.
5. Özkan M, Gündüz S, Gürsoy OM. Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial. Am Heart J. 2015 Aug;170(2):409-18.
6. NIcolas D, Michel P, Denis B. Prosthetic valve thrombosis: twenty-year experience at the Montreal Heart Institute Surgery for acquired cardiovascular disease. 01 May 2004;127(5):1388-92
7. Mustafa A, Thomas T, Murdock R. Modified fibrinolytic therapy as treatment of mechanical aortic valve thrombosis. SAGE Open Med Case Rep. 2021 Mar 17;9:2050313X21999202.
8. Rizzoli G, Guglielmi C, Toscano G. Reoperations for acute prosthetic thrombosis and pannus: An assessment of rates, relationship and risk. Eur J Cardiothorac Surg. 1999 Jul;16(1):74-80.
9. Bortolotti U, Milano A, Mossuto E. Early and late outcome after reoperation for prosthetic valve dysfunction: Analysis of 549 patients during a 26-year period. J Heart Valve Dis. 1994 Jan;3(1):81-7.
10. Lengyel M, Horstkotte D, Völler H. Recommendations for the management of prosthetic valve thrombosis. J Heart Valve Dis. 2005 Sep;14(5):567-75.
11. Castilho FM, De Sousa MR, Mendonça ALP. Thrombolytic therapy or surgery for valve prosthesis thrombosis: Systematic review and meta-analysis. J Thromb Haemost. 2014 Aug;12(8):1218-28.
12. Özkan M, Gündüz S, Biteker M et al. Comparison of different TEE-guided thrombolytic regimens for prosthetic valve thrombosis: The TROIA trial. JACC Cardiovasc Imaging. Feb 2013;6(2):206-16.
13. Huang F, Lan Y, Cheng Z. Thrombolytic treatment of prosthetic valve thrombosis: A study using Urokinase. Journal of Cardiothoracic Surgery. 01 October 2020;15(1):286.