Investigation of PD-L1 RS4143815 polymorphism and serum PD-L1 levels in patients with chronic HBV infection
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Abstract
The study was conducted to investigate the polymorphism of PD-L1 rs4143815 by using tetra-primer-ARMS technique and protein PD-L1 levels were analyzed by Elisa in patients with chronic hepatitis B virus (HBV) infection and healthy controls. The study participants included 127 chronic HBV patients, 157 hepatocellular carcinoma (HCC) patients, and 240 healthy controls. Results showed that there was no significant difference in genotype frequencies between HBV patients and healthy controlled group, and between CHB group and HCC group. Chronic HBV patients had higher PD-L1 level than healthy patients, and PD-L1 level correlates with clinical features and progress of disease in chronic hepatitis B virus infection.
Article Details
Keywords
HBV, Chronic hepatitis B virus, Hepatocellular carcinoma, PD-L1, rs4143815
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