22. BK virus infection in kidney transplant patients of Bach Mai Hospital

Nguyen Anh Thu, Do Gia Tuyen, Mai Thi Hien

Main Article Content

Abstract

BK virus and BK virus nephropathy can lead to graft failure in kidney transplant. However, in clinical settings, monitoring and detecting BK virus infection remains a challenge. This study described the clinical characteristics of BK virus infection and explored factors associated with infection in patients who had kidney transplantation with follow-up visits at Bach Mai Hospital from January 2018 to June 2022. Among the 81 patients in the study, 31 had BK virus infection (38.3%), of which, there were 20 patients with simple BK viruria (24.7%) and 11 patients with viremia (14.6%). There were 4/28 (14.3%) patients whose kidney biopsy confirmed BK virus nephropathy. BK virus infection was related to the use of Tacrolimus with dose higher than 7 ng/ml, low glomerular filtration rate, and graft failure.

Article Details

References

1. Lee S, Lee KW, Kim SJ, Park JB. Clinical characteristic and outcomes of BK virus infection in kidney transplant recipients managed using a systematic surveillance and treatment strategy. Transplantation Proceedings. 2020;52(6):1749-1756. doi: 10.1016/j.transproceed.2020.01.158.
2. Boobes Y, Bernieh B, Hussain Q, et al. Prevalence of polyomavirus among United Arab Emirates kidney transplant recipients: Results from a single center. Transplantation Proceedings. 2015;47(4):1143-1145. doi: 10.1016/j.transproceed.2014.11.060.
3. Hirsch HH, Brennan DC, Drachenberg CB, et al. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation. 2005;79(10):1277-1286. doi: 10.1097/01.tp.0000156165.83160.09.
4. Nickeleit V, Hirsch HH, Binet IF, et al. Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease. J Am Soc Nephrol. 1999 May;10(5):1080-9. doi: 10.1681/ASN.V1051080.
5. Chantrel F, de Cornelissen F, Deloumeaux J, Lange C, Lassalle M, REIN registre. Survival and mortality in ESRD patients. Nephrologie & Therapeutique. 2013;9 Suppl 1:S127-137. doi: 10.1016/S1769-7255(13)70042-7.
6. Toan PQ, Bao Quyen LT, Thu Hang DT, et al. Identification of BK virus genotypes in recipients of renal transplant in Vietnam. Transplantation Proceedings. 2019;51(8):2683-2688. doi: 10.1016/j.transproceed.2019.03.072.
7. Kong XR, Li XB, Sun YJ, Zhang TY, Xiao L, Shi BY. Analysis of BK virus infection in kidney transplant recipients. Zhonghua Yi Xue Za Zhi. 2020;100(48):3859-3862. doi: 10.3760/cma.j.cn112137-20200817-02404.
8. Bohl DL, Brennan DC. BK virus nephropathy and kidney transplantation. Clinical Journal of the American Society of Nephrology. 2007;2(Supplement 1):S36-S46. doi: 10.2215/CJN.00920207.
9. Skulratanasak P, Mahamongkhonsawata J, Chayakulkeereeb M, Larpparisutha N, Premasathiana N, Vongwiwatana A. BK Virus Infection in Thai Kidney Transplant Recipients: A Single-Center Experience. Transplant Proc. 2018;50(4):1077-1079. doi:10.1016/j.transproceed.2018.02.047
10. Premathilake MI, Jayamaha JS, Lanerolle RD. Prevalence of BK virus among renal transplant recipients in a tertiary care hospital in Sri Lanka. The Ceylon Medical Journal. 2018;63(3):124-128. doi: 10.4038/cmj.v63i3.8716.
11. Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients. American Journal of Transplantation. 2009;9(s3):S1-S155. doi: 10.1111/j.1600-6143.2009.02834.x.
12. Dall A, Hariharan S. BK virus nephritis after renal transplantation. Clin J Am Soc Nephrol. 2008;3(Suppl 2):S68-S75. doi: 10.2215/CJN.02770707.
13. Rocha PN, Plumb TJ, Miller SE, Howell DN, Smith SR. Risk factors for BK polyomavirus nephritis in renal allograft recipients. Clinical Transplantation. 2004;18(4):456-462. doi: 10.1111/j.1399-0012.2004.00191.x.
14. Ramos E, Drachenberg CB, Papadimitriou JC, et al. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. Journal of the American Society of Nephrology: JASN. 2002;13(8):2145-2151. doi: 10.1097/01.asn.0000023435.07320.81.
15. Helanterä I, Egli A, Koskinen P, Lautenschlager I, Hirsch HH. Viral impact on long-term kidney graft function. Infect Dis Clin North Am. 2010;24(2):339-371. doi: 10.1016/j.idc.2010.02.003.