29. Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (gist) in the stomach: Case report

Dang Tien Ngoc, Trinh Hong Son, Nguyen Dang Vung, Ho Duc Thuong, Le Van Tinh

Main Article Content

Abstract

Adenocarcinomas and gastrointestinal stromal tumors (GISTs) are two distinct types of tumors that originate from different cell layers of the digestive tract. Co-development of these two types of tumors in the stomach is rare. We report a case of synchronous development of adenocarcinoma and GIST in the stomach. The patient was male and 61 years old. Gastric endoscopy was done in antrum area showing 2x3cm wart ulcer and 3cm diameter submucosal tumor. The patient underwent lower pole gastrectomy and pean anastomosis. Histopathology and immunohistochemistry showed moderately differentiated adenocarcinoma, no lymph node metastasis (T2N0M0) and low-risk GIST. At 50 months after surgery, the patient’s condition was stable; the anastomosis was good; and there was no sign of recurrence and metastasis.

Article Details

References

1. Yamamoto D, Hamada Y, Tsubota Y, Kawakami K, Yamamoto C, Yamamoto M. Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: a case report. World J Surg Oncol. 2012 Jan 9; 10:6.
2. Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF: Gastrointestinal stromal tumors. current diagnosis, biologic behavior, and management. Ann Surg Oncol 2000, 7: 705-12.3.
3. Rabin I, Chikman B, Lavy R, Sandbank J, Maklakovsky M, Gold-Deutch R: Gastrointestinal stromal tumors: a 19year experience. Isr Med Assoc J 2009, 11: 98-102.4.
4. Bircan S, Candir O, Aydin S, Baspinar S, Bulbul M, Kapucuoglu M, Karahan N, Ciris M: Synchronous primary adenocarcinoma and gastrointestinal stromal tumour in the stomach. a report of two cases. Turk J Gastroenterol 2004, 15: 187-191.5.
5. Katsoulis IE, Bossi M, Richman PI, Livingstone JI. Collision of adenocarcinoma and gastrointestinal stromal tumour (GIST) in the stomach: Report of a case. Int Semin Surg Oncol. 2007; 4:2.
6. Rauf F, Ahmad Z, Muzzafar S, Hussaini AS: Synchronous occurrence of gastrointestinal stromal tumour and gastric adenocarcinoma. a case report. J Pak Med Assoc 2006, 56: 184-186.6.
7. Maiorana A, Fante R, Maria Cesinaro A, Adriana Fano R: Synchronous occurrence of epithelial and stromal tumors in the stomach. a report of 6 cases. Arch Pathol Lab Med 2000, 124: 682-686.
8. Liu SW, Chen GH, Hsieh PP: Collision tumor of the Stomach. A case report of Mixed Stromal Tumour and Adenocarcinoma. J Clin Gastroenterol 2002, 35: 332-334.8.
9. Kaffes A, Hughes L, Hollinshead J, Katelaris P: Synchronous primary adenocarcinoma, mucosa-associated lymphoid tissue lymphoma and a stromal tumor in a Helicobacter pylori- infected stomach. J Gastroenterol Hepatol 2002, 17: 1033-1036.
10. Goteri G, Ranaldi R, Rezai B, Baccarini MG, Bearzi I. Synchronous mucosa-associated lymphoid tissue lymphoma and adenocarcinoma of the stomach. Am J Surg Pathol. 1997; 21: 505–9.
11. Sailors JJ, French SW. The unique simultaneous occurrence of granular cell tumor, gastrointestinal stromal tumor, and gastric adenocarcinoma. Arch Pathol Lab Med. 2005; 129: 121-3.
12. Fletcher CD, Berman JJ, Corless C: Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002, 33: 459-65.
13. Ng EH, Pollock RE, Munsell MF, Atkinson EN, Romsdahl MM. Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging. Ann Surg. 1992; 215: 68–77.