Clinical symptoms, endoscopic findings and high resolution manometryc results in patients with distal esophageal spasm
Main Article Content
Abstract
A retrospective study was conducted to describe clinical symptoms, endoscopic findings, and high-resolution manometry (HRM) results in patients with distal esophageal spasm (DES). There were 75 of 7519 patients diagnosed of DES on HRM between 3/2018 to 8/2020 at the Institute of Gastroenterology and Hepatology. The study sample included 62.7% women, the mean age was 47.8 years. The prevalence of dysphagia and chest pain were 41.3% and 30.7%, respectively. Other common symptoms included regurgitation (72.0%), belching (56.0%), and heartburn (49.3%). 46.8% of patients had erosive esophagitis on endoscopy. On HRM, the median percentage of premature swallows was 30%. Patients with dysphagia with or without chest pain had significantly higher 4-second integrated relaxation pressure (IRP4s) than those without these symptoms. There was no correlation between dysphagia or chest pain and the percentage of premature contraction.
Article Details
Keywords
distal esophageal spasm, esophageal manometry
References
2. Gorti H, Samo S, Shahnavaz N, Qayed E. Distal esophageal spasm: Update on diagnosis and management in the era of high-resolution manometry. World J Clin Cases. 2020;8(6):1026-1032.
3. Paterson WG. Esophageal peristalsis. GI Motility online. 2006.
4. Almansa C, Heckman MG, DeVault KR, Bouras E, Achem SR. Esophageal spasm: demographic, clinical, radiographic, and manometric features in 108 patients. Dis Esophagus. 2012;25(3):214-221.
5. Tsuboi K, Mittal SK. Diffuse esophageal spasm: has the term lost its relevance? Analysis of 217 cases. Dis Esophagus. 2011;24(5):354-359.
6. Katz PO, Dalton CB, Richter JE, Wu WC, Castell DO. Esophageal testing of patients with noncardiac chest pain or dysphagia. Results of three years’ experience with 1161 patients. Ann Intern Med. 1987;106(4):593-597.
7. Rosen JM, Lavenbarg T, Cocjin J, Hyman PE. Diffuse esophageal spasm in children referred for manometry. J Pediatr Gastroenterol Nutr. 2013;56(4):436-438.
8. Almansa C, Achem SR. [Diffuse esophageal spasm (DES). Practical concepts of diagnosis and treatment]. Revista de gastroenterologia de Mexico. 2007;72(2):136-145.
9. Crespin OM, Tatum RP, Yates RB, et al. Esophageal hypermotility: cause or effect? Dis Esophagus. 2016;29(5):497-502.
10. Clouse RE, Staiano A. Contraction abnormalities of the esophageal body in patients referred to manometry. A new approach to manometric classification. Digestive diseases and sciences. 1983;28(9):784-791.
11. Reidel WL, Clouse RE. Variations in clinical presentation of patients with esophageal contraction abnormalities. Digestive diseases and sciences. 1985;30(11):1065-1071.
12. Đào Việt Hằng, Trần Thị Thanh Lịch, Lưu Thị Minh Huế. Mối liên quan giữa điểm FSSG với nhu động thực quản và áp lực cơ thắt thực quản dưới ở bệnh nhân trào ngược dạ dày thực quản. Tạp chí nghiên cứu Y học. 2020;130(6):83-90.
13. Nguyễn Thùy Linh, Trần Thị Thu Trang, Lưu Thị Minh Huế, Đào Việt Hằng. Evaluation of clinical characteristics and lower esophageal sphincter pressure on high resolution manomoetry in achalasia patients after treatment. Tạp chí Khoa học và Công nghệ Việt Nam. 2020;accepted.
14. Khatami SS, Khandwala F, Shay SS, Vaezi MF. Does diffuse esophageal spasm progress to achalasia? A prospective cohort study. Digestive diseases and sciences. 2005;50(9):1605-1610.
15. Fontes LH, Herbella FA, Rodriguez TN, Trivino T, Farah JF. Progression of diffuse esophageal spasm to achalasia: incidence and predictive factors. Dis Esophagus. 2013;26(5):470-474.
16. Liu L, Li S, Zhu K, et al. Relationship between esophageal motility and severity of gastroesophageal reflux disease according to the Los Angeles classification. Medicine. 2019;98(19):e15543.
17. Chrysos E, Prokopakis G, Athanasakis E, et al. Factors affecting esophageal motility in gastroesophageal reflux disease. Archives of surgery (Chicago, Ill : 1960). 2003;138(3):241-246.
18. Lin S, Li H, Fang X. Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives. Journal of neurogastroenterology and motility. 2019;25(4):499-507.
19. Achem SR, Gerson LB. Distal esophageal spasm: an update. Curr Gastroenterol Rep. 2013;15(9):325.