29. Một số yếu tố ảnh hưởng đến khả năng đạt đích nồng độ đáy vancomycin trong điều trị viêm màng não phế cầu ở trẻ em

Abstract

Vancomycin is an antibiotic that plays an important role in the treatment of pneumococcal meningitis. In order to have the scientific basis and necessary data to establish an optimal dose regimen for children with pneumococcal meningitis, we conducted this study with goals “To investigate the vancomycin concentration and factors predicting the probably to attain the trough concentration target at the first measurement in treatment of pneumococcal meningitis”. Retrospective, cross-sectional study on 37 cases of pneumococcal meningitis, whose were monitored the vancomycin serum level at the Center for Tropical Diseases, National Children’s Hospital since July 2020 to July 2022. The proportion of patients who reached target trough levels at the first measurement was 24.3%. Univariate analysis of factors associated with subtherapeutic trough levels showed that age group, renal function, shock on admission are statistically significant factors. Conclusion: Vancomycin dose of 60 mg/kg/day is insufficient to attain target trough levels for most of the children having pneumococcal meningitis. Patients with shock on admission have a lower risk of subtherapeutic trough concentrations than patients without shock.