34. A systemic review of injectable platelet rich fibrin in periodontal treatment
Main Article Content
Abstract
Platelet concentrate and its generations have been used in dentistry for more than three decades. Their last generations were developed with more optimal characteristics, especially injectable platelet-rich fibrin - i-PRF. The main difference of i-PRF from other solid-PRF is a slower and shorter centrifugation spin which lead to a higher cell numbers and growth factors, supporting accelerated healing injury and enhance blood vessels formation. 214 articles about i-PRF and periodontal treatment were found from Pubmed, Embase and Google Scholar sources. 12 articles met the selection criteria and were divided into 4 groups: case reports, animal trials, clinical trials of non-surgical and surgical treatment. Animal testing showed no difference with the combination of i-PRF. However, clinical trials showed significant reductions in PPD and CAL. Surgical clinical trial demonstrates the potential of i-PRF in combination with bone graft which was called sticky bone. I-PRF is a potential and promising material for tissue regeneration, especially periodontal tissue.
Article Details
Keywords
injectable platelet-rich fibrin, periodontal treatment, systemic review
References
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2. Caruana A, Savina D, Macedo JP, Soares SC. From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery. Eur J Dent. May 2019;13(2):280-286. doi: 10.1055/s-0039-1696585.
3. Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. Feb 2018;44(1):87-95. doi: 10.1007/s00068-017-0767-9.
4. Mourão CF, Valiense H, Melo ER, Mourão NB, Maia MD. Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: Technical note. Rev Col Bras Cir. Nov-Dec 2015;42(6):421-3. doi: 10.1590/0100-69912015006013.
5. Miron RJ, Fujioka-Kobayashi M, Hernandez M, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. Nov 2017;21(8):2619-2627. doi: 10.1007/s00784-017-2063-9.
6. Karde PA, Sethi KS, Mahale SA, Khedkar SU, Patil AG, Joshi CP. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. J Indian Soc Periodontol. Mar-Apr 2017;21(2):97-101. doi: 10.4103/jisp.jisp_201_17.
7. Miron RJ, Choukroun J. Platelet rich fibrin in regenerative dentistry: biological background and clinical indications. John Wiley & Sons; 2017.
8. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets. 2018/01/02 2018;29(1):48-55. doi: 10.1080/09537104.2017.1293807.
9. Jasmine S, Thangavelu A, Janarthanan K, et al. Antimicrobial and antibiofilm potential of injectable platelet rich fibrin-a second-generation platelet concentrate-against biofilm producing oral staphylococcus isolates. Saudi J Biol Sci. Jan 2020;27(1):41-46. doi: 10.1016/j.sjbs.2019.04.012.
10. Kour P, Pudakalkatti PS, Vas AM, Das S, Padmanabhan S. Comparative Evaluation of Antimicrobial Efficacy of Platelet-rich Plasma, Platelet-rich Fibrin, and Injectable Platelet-rich Fibrin on the Standard Strains of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Contemp Clin Dent. Sep 2018;9(Suppl 2):S325-s330. doi: 10.4103/ccd.ccd_367_18.
11. Farshidfar N, Amiri MA, Jafarpour D, Hamedani S, Niknezhad SV, Tayebi L. The feasibility of injectable PRF (I-PRF) for bone tissue engineering and its application in oral and maxillofacial reconstruction: From bench to chairside. Biomater Adv. Mar 2022;134:112557. doi: 10.1016/j.msec.2021.112557.
12. Hải PN. Điều trị viêm huyệt ổ răng khô bằng fibrin giàu tiểu cầu: báo cáo trường hợp lâm sàng. Tạp chí Y học Việt Nam. 2022;513:180-183.
13. Farshidfar N, Jafarpour D, Firoozi P, et al. The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review of In vitro and In vivo studies. Jpn Dent Sci Rev. Nov 2022;58:89-123. doi: 10.1016/j.jdsr.2022.02.003.
14. Lei L, Yu Y, Ke T, Sun W, Chen L. The Application of Three-Dimensional Printing Model and Platelet-Rich Fibrin Technology in Guided Tissue Regeneration Surgery for Severe Bone Defects. J Oral Implantol. Feb 2019;45(1):35-43. doi: 10.1563/aaid-joi-D-17-00231.
15. Shah R, Triveni M, Thomas R, Kumar A, Mehta D. Clinical applications of injectable platelet-rich fibrin: A case series. Case Report. Journal of Interdisciplinary Dentistry. January 1, 2022 2022;12(1):11-14. doi: 10.4103/jid.jid_87_20.
16. Aydinyurt HS, Sancak T, Taskin C, Basbugan Y, Akinci L. Effects of ınjectable platelet-rich fibrin in experimental periodontitis in rats. Odontology. Apr 2021;109(2):422-432. doi: 10.1007/s10266-020-00557-1.
17. Mila V NN, Jelena M, et al. The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. Serbian archives of medicine. 2020;148(5-6):280-285. doi: https://doi.org/10.2298/SARH190925022V
18. Albonni H, El Abdelah A, Al Hamwi M, Al Hamoui WB, Sawaf H. Clinical effectiveness of a topical subgingival application of injectable platelet-rich fibrin as adjunctive therapy to scaling and root planing: A double-blind, split-mouth, randomized, prospective, comparative controlled trial. Quintessence Int. Jul 20 2021;52(8):676-685. doi: 10.3290/j.qi.b1492019.
19. Elarif AM. Comparison between antimicrobial photodynamic therapy and injectable platelet rich fibrin as an adjunct to non-surgical periodontal treatment (a randomized controlled clinical trial with microbiological assessment). Egyptian dental journal. 2022;68(4):3273-3283. doi: 10.21608/edj.2022.146616.2170.
20. Amin A-RE. Comparison between prp vs iprf as an adjunct therapy in infra-bony pocket treatment. Al-Azhar Journal of Dental Science. 2022;25(4):485-494. doi: 10.21608/ajdsm.2022.121791.1311.
21. D’sa E CA, Shetty DN, Pradeep AR. Clinical evaluation and comparison of platelet-rich fibrin and injectable platelet-rich fibrin (sticky bone) in the treatment of intrabony defects. Niger J Exp Clin Biosci. 2020;8:78-85.
22. D.V KPMaN. Injectable Platelet Richfibrin (I-Prf) – A “Wonder” in Periodontal Therapy. International Journal of Current Advanced Research. 2020;9 (04(A)):21831-21844. doi: http://dx.doi.org/10.24327/ijcar.2020.21844.4300.
23. Liu K, Huang Z, Chen Z, Han B, Ouyang X. Treatment of periodontal intrabony defects using bovine porous bone mineral and guided tissue regeneration with/without platelet-rich fibrin: A randomized controlled clinical trial. J Periodontol. Nov 2021;92(11):1546-1553. doi: 10.1002/jper.20-0860.
24. ELaziz AEARAA. Evaluation of the Addition of Injectable Platelet Rich Fibrin to Xenograft in Management of Periodontal Intraosseous Defects: Randomized Controlled Trial. AL-AZHAR Dental Journal. 2022;9(2):321-330. doi: 10.21608/adjg.2022.111166.1461.
25. Nair UP, Shivamurthy R, Nagate RR, et al. Effect of Injectable Platelet-Rich Fibrin with a Nano-Hydroxyapatite Bone Graft on the Treatment of a Grade II Furcation Defect. Bioengineering. 2022;9(11):602.
26. Harmon K, et al. Guidelines for the use of platelet rich plasma. The International Cellular Medical Society;2011.
27. Tewari NKK, Vivek; Choubey, Neha; Tiwari, Sushmita. Platelet Rich Fibrin Membrane Grafting After Laser Excision for Oral Mucosal Lesions. Indian Journal of Otolaryngology & Head & Neck Surgery 2020:1-7.
28. Yajamanya SR, Chatterjee A, Babu CN, Karunanithi D. Fibrin network pattern changes of platelet-rich fibrin in young versus old age group of individuals: A cell block cytology study. J Indian Soc Periodontol. Mar-Apr 2016;20(2):151-6. doi: 10.4103/0972-124x.176390.
29. Das N, Amaranath BJJ. Qualitative Analysis of Modified Advanced-Platelet-Rich Fibrin Buffy Coat among Diabetic Patients and Tobacco Smokers with Chronic Periodontitis: A Cell Block Cytology Study. Contemp Clin Dent. Apr-Jun 2022;13(2):173-182. doi: 10.4103/ccd.ccd_1018_20.
30. Chatterjee A, Debnath K, Ali MM, Babu C, Gowda PL. Comparative histologic evaluation of titanium platelet-rich fibrin and platelet-rich fibrin in hypertensive and smoker participants: A cell cytology study. J Indian Soc Periodontol. May-Jun 2017;21(3):195-200. doi: 10.4103/jisp.jisp_137_17.
31. Herrera-Vizcaino C. Systematic review of platelet-rich fibrin (PRF) centrifugation protocols in oral and maxillofacial surgery and the introduction of AR 2 T 3 : an easy to remember acronym to correctly report vertical and horizontal PRF centrifugation. Frontiers of Oral and Maxillofacial Medicine. 2021.
32. Phuong Tran TT, Vu Pham TA. Effect of advanced and injectable platelet-rich fibrins against Aggregatibacter actinomycetemcomitans in subjects with or without periodontal diseases. Journal of Dental Sciences. 2022/10/06/ 2022;doi: https://doi.org/10.1016/j.jds.2022.09.014.
33. Fujioka-Kobayashi M, Kono M, Katagiri H, et al. Histological comparison of Platelet rich fibrin clots prepared by fixed-angle versus horizontal centrifugation. Platelets. Apr 3 2021;32(3):413-419. doi: 10.1080/09537104.2020.1754382.
34. Lourenço ES, Mourão C, Leite PEC, Granjeiro JM, Calasans-Maia MD, Alves GG. The in vitro release of cytokines and growth factors from fibrin membranes produced through horizontal centrifugation. J Biomed Mater Res A. May 2018;106(5):1373-1380. doi: 10.1002/jbm.a.36346.
35. Miron RJ, Chai J, Zheng S, Feng M, Sculean A, Zhang Y. A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation. J Biomed Mater Res A. Oct 2019;107(10):2257-2271. doi: 10.1002/jbm.a.36734.
36. Thanasrisuebwong P, Surarit R, Bencharit S, Ruangsawasdi N. Influence of Fractionation Methods on Physical and Biological Properties of Injectable Platelet-Rich Fibrin: An Exploratory Study. Int J Mol Sci. Apr 3 2019;20(7). doi: 10.3390/ijms20071657.
37. Thanasrisuebwong P, Kiattavorncharoen S, Surarit R, Phruksaniyom C, Ruangsawasdi N. Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation. Int J Mol Sci. Jul 21 2020;21(14). doi: 10.3390/ijms21145153.
38. Lajos Csönge ÁB, Zoltán Tóth Bagi et al. Word of caution: negative impact of mouthwashes on folded Platelet-Rich Fibrin (F- PRF) membrane viability. Research Square. 2021. doi: 10.21203/rs.3.rs-990808/v1.
2. Caruana A, Savina D, Macedo JP, Soares SC. From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery. Eur J Dent. May 2019;13(2):280-286. doi: 10.1055/s-0039-1696585.
3. Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. Feb 2018;44(1):87-95. doi: 10.1007/s00068-017-0767-9.
4. Mourão CF, Valiense H, Melo ER, Mourão NB, Maia MD. Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: Technical note. Rev Col Bras Cir. Nov-Dec 2015;42(6):421-3. doi: 10.1590/0100-69912015006013.
5. Miron RJ, Fujioka-Kobayashi M, Hernandez M, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. Nov 2017;21(8):2619-2627. doi: 10.1007/s00784-017-2063-9.
6. Karde PA, Sethi KS, Mahale SA, Khedkar SU, Patil AG, Joshi CP. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. J Indian Soc Periodontol. Mar-Apr 2017;21(2):97-101. doi: 10.4103/jisp.jisp_201_17.
7. Miron RJ, Choukroun J. Platelet rich fibrin in regenerative dentistry: biological background and clinical indications. John Wiley & Sons; 2017.
8. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets. 2018/01/02 2018;29(1):48-55. doi: 10.1080/09537104.2017.1293807.
9. Jasmine S, Thangavelu A, Janarthanan K, et al. Antimicrobial and antibiofilm potential of injectable platelet rich fibrin-a second-generation platelet concentrate-against biofilm producing oral staphylococcus isolates. Saudi J Biol Sci. Jan 2020;27(1):41-46. doi: 10.1016/j.sjbs.2019.04.012.
10. Kour P, Pudakalkatti PS, Vas AM, Das S, Padmanabhan S. Comparative Evaluation of Antimicrobial Efficacy of Platelet-rich Plasma, Platelet-rich Fibrin, and Injectable Platelet-rich Fibrin on the Standard Strains of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Contemp Clin Dent. Sep 2018;9(Suppl 2):S325-s330. doi: 10.4103/ccd.ccd_367_18.
11. Farshidfar N, Amiri MA, Jafarpour D, Hamedani S, Niknezhad SV, Tayebi L. The feasibility of injectable PRF (I-PRF) for bone tissue engineering and its application in oral and maxillofacial reconstruction: From bench to chairside. Biomater Adv. Mar 2022;134:112557. doi: 10.1016/j.msec.2021.112557.
12. Hải PN. Điều trị viêm huyệt ổ răng khô bằng fibrin giàu tiểu cầu: báo cáo trường hợp lâm sàng. Tạp chí Y học Việt Nam. 2022;513:180-183.
13. Farshidfar N, Jafarpour D, Firoozi P, et al. The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review of In vitro and In vivo studies. Jpn Dent Sci Rev. Nov 2022;58:89-123. doi: 10.1016/j.jdsr.2022.02.003.
14. Lei L, Yu Y, Ke T, Sun W, Chen L. The Application of Three-Dimensional Printing Model and Platelet-Rich Fibrin Technology in Guided Tissue Regeneration Surgery for Severe Bone Defects. J Oral Implantol. Feb 2019;45(1):35-43. doi: 10.1563/aaid-joi-D-17-00231.
15. Shah R, Triveni M, Thomas R, Kumar A, Mehta D. Clinical applications of injectable platelet-rich fibrin: A case series. Case Report. Journal of Interdisciplinary Dentistry. January 1, 2022 2022;12(1):11-14. doi: 10.4103/jid.jid_87_20.
16. Aydinyurt HS, Sancak T, Taskin C, Basbugan Y, Akinci L. Effects of ınjectable platelet-rich fibrin in experimental periodontitis in rats. Odontology. Apr 2021;109(2):422-432. doi: 10.1007/s10266-020-00557-1.
17. Mila V NN, Jelena M, et al. The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. Serbian archives of medicine. 2020;148(5-6):280-285. doi: https://doi.org/10.2298/SARH190925022V
18. Albonni H, El Abdelah A, Al Hamwi M, Al Hamoui WB, Sawaf H. Clinical effectiveness of a topical subgingival application of injectable platelet-rich fibrin as adjunctive therapy to scaling and root planing: A double-blind, split-mouth, randomized, prospective, comparative controlled trial. Quintessence Int. Jul 20 2021;52(8):676-685. doi: 10.3290/j.qi.b1492019.
19. Elarif AM. Comparison between antimicrobial photodynamic therapy and injectable platelet rich fibrin as an adjunct to non-surgical periodontal treatment (a randomized controlled clinical trial with microbiological assessment). Egyptian dental journal. 2022;68(4):3273-3283. doi: 10.21608/edj.2022.146616.2170.
20. Amin A-RE. Comparison between prp vs iprf as an adjunct therapy in infra-bony pocket treatment. Al-Azhar Journal of Dental Science. 2022;25(4):485-494. doi: 10.21608/ajdsm.2022.121791.1311.
21. D’sa E CA, Shetty DN, Pradeep AR. Clinical evaluation and comparison of platelet-rich fibrin and injectable platelet-rich fibrin (sticky bone) in the treatment of intrabony defects. Niger J Exp Clin Biosci. 2020;8:78-85.
22. D.V KPMaN. Injectable Platelet Richfibrin (I-Prf) – A “Wonder” in Periodontal Therapy. International Journal of Current Advanced Research. 2020;9 (04(A)):21831-21844. doi: http://dx.doi.org/10.24327/ijcar.2020.21844.4300.
23. Liu K, Huang Z, Chen Z, Han B, Ouyang X. Treatment of periodontal intrabony defects using bovine porous bone mineral and guided tissue regeneration with/without platelet-rich fibrin: A randomized controlled clinical trial. J Periodontol. Nov 2021;92(11):1546-1553. doi: 10.1002/jper.20-0860.
24. ELaziz AEARAA. Evaluation of the Addition of Injectable Platelet Rich Fibrin to Xenograft in Management of Periodontal Intraosseous Defects: Randomized Controlled Trial. AL-AZHAR Dental Journal. 2022;9(2):321-330. doi: 10.21608/adjg.2022.111166.1461.
25. Nair UP, Shivamurthy R, Nagate RR, et al. Effect of Injectable Platelet-Rich Fibrin with a Nano-Hydroxyapatite Bone Graft on the Treatment of a Grade II Furcation Defect. Bioengineering. 2022;9(11):602.
26. Harmon K, et al. Guidelines for the use of platelet rich plasma. The International Cellular Medical Society;2011.
27. Tewari NKK, Vivek; Choubey, Neha; Tiwari, Sushmita. Platelet Rich Fibrin Membrane Grafting After Laser Excision for Oral Mucosal Lesions. Indian Journal of Otolaryngology & Head & Neck Surgery 2020:1-7.
28. Yajamanya SR, Chatterjee A, Babu CN, Karunanithi D. Fibrin network pattern changes of platelet-rich fibrin in young versus old age group of individuals: A cell block cytology study. J Indian Soc Periodontol. Mar-Apr 2016;20(2):151-6. doi: 10.4103/0972-124x.176390.
29. Das N, Amaranath BJJ. Qualitative Analysis of Modified Advanced-Platelet-Rich Fibrin Buffy Coat among Diabetic Patients and Tobacco Smokers with Chronic Periodontitis: A Cell Block Cytology Study. Contemp Clin Dent. Apr-Jun 2022;13(2):173-182. doi: 10.4103/ccd.ccd_1018_20.
30. Chatterjee A, Debnath K, Ali MM, Babu C, Gowda PL. Comparative histologic evaluation of titanium platelet-rich fibrin and platelet-rich fibrin in hypertensive and smoker participants: A cell cytology study. J Indian Soc Periodontol. May-Jun 2017;21(3):195-200. doi: 10.4103/jisp.jisp_137_17.
31. Herrera-Vizcaino C. Systematic review of platelet-rich fibrin (PRF) centrifugation protocols in oral and maxillofacial surgery and the introduction of AR 2 T 3 : an easy to remember acronym to correctly report vertical and horizontal PRF centrifugation. Frontiers of Oral and Maxillofacial Medicine. 2021.
32. Phuong Tran TT, Vu Pham TA. Effect of advanced and injectable platelet-rich fibrins against Aggregatibacter actinomycetemcomitans in subjects with or without periodontal diseases. Journal of Dental Sciences. 2022/10/06/ 2022;doi: https://doi.org/10.1016/j.jds.2022.09.014.
33. Fujioka-Kobayashi M, Kono M, Katagiri H, et al. Histological comparison of Platelet rich fibrin clots prepared by fixed-angle versus horizontal centrifugation. Platelets. Apr 3 2021;32(3):413-419. doi: 10.1080/09537104.2020.1754382.
34. Lourenço ES, Mourão C, Leite PEC, Granjeiro JM, Calasans-Maia MD, Alves GG. The in vitro release of cytokines and growth factors from fibrin membranes produced through horizontal centrifugation. J Biomed Mater Res A. May 2018;106(5):1373-1380. doi: 10.1002/jbm.a.36346.
35. Miron RJ, Chai J, Zheng S, Feng M, Sculean A, Zhang Y. A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation. J Biomed Mater Res A. Oct 2019;107(10):2257-2271. doi: 10.1002/jbm.a.36734.
36. Thanasrisuebwong P, Surarit R, Bencharit S, Ruangsawasdi N. Influence of Fractionation Methods on Physical and Biological Properties of Injectable Platelet-Rich Fibrin: An Exploratory Study. Int J Mol Sci. Apr 3 2019;20(7). doi: 10.3390/ijms20071657.
37. Thanasrisuebwong P, Kiattavorncharoen S, Surarit R, Phruksaniyom C, Ruangsawasdi N. Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation. Int J Mol Sci. Jul 21 2020;21(14). doi: 10.3390/ijms21145153.
38. Lajos Csönge ÁB, Zoltán Tóth Bagi et al. Word of caution: negative impact of mouthwashes on folded Platelet-Rich Fibrin (F- PRF) membrane viability. Research Square. 2021. doi: 10.21203/rs.3.rs-990808/v1.